Browsing Investigación Aplicada by Title
Now showing items 9-28 of 225
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Argentinian clinical genomics in a leukodystrophies and genetic leukoencephalopathies cohort: Diagnostic yield in our first 9 years
(Wiley, 2020-01)Abstract Introduction and objectives: Leukodystrophies and genetic leukoencephalopathies constitute a vast group of pathologies of the cerebral white matter. The large number of etiopathogenic genes and the frequent ... -
Argentinian clinical practice guideline for surveillance, diagnosis, staging and treatment of hepatocellular carcinoma
(Elsevier, 2020-10)Abstract The A.A.E.E.H has developed this guideline for the best care of patients with hepatocellular carcinoma (HCC) from Argentina. It was done from May 2018 to March 2020. Specific clinical research questions were ... -
Association Between Cigarette Smoking Prevalence and Income Level: A Systematic Review and Meta-Analysis
(Oxford University Press, 2016-10-26)Introduction Previous evidence linked low socioeconomic status with higher smoking prevalence. Our objective was to assess the strength of this association in the world population, updating a previous work. Methods Systematic ... -
Association Between Cigarette Smoking Prevalence and Income Level: A Systematic Review and Meta-Analysis.
(Oxford University Press, 2017-09)INTRODUCTION: Previous evidence linked low socioeconomic status with higher smoking prevalence. Our objective was to assess the strength of this association in the world population, updating a previous work. METHODS: ... -
Axotomy of tributaries of the pelvic and pudendal nerves induces changes in the neurochemistry of mouse dorsal root ganglion neurons and the spinal cord.
(Springer Nature Switzerland AG. Springer is part of Springer Nature, 2016-05-01)Using immunohistochemical techniques, we characterized changes in the expression of several neurochemical markers in lumbar 4-sacral 2 (L4-S2) dorsal root ganglion (DRG) neuron profiles (NPs) and the spinal cord of BALB/c ... -
Bilateral macular detachment: Choroid as a sanctuary of acute lymphoblastic leukemia
(Elsevier, 2020-05)Abstract Purpose: To describe a bilateral macular detachment as the only sign of acute lymphoblastic leukemia relapse and prompt reversal with total body irradiation without ocular protection. Observations: We present ... -
Biomarker-driven phenotyping in Parkinson's disease: A translational missing link in disease-modifying clinical trials.
(Wiley, 2017-02-24)Past clinical trials of putative neuroprotective therapies have targeted PD as a single pathogenic disease entity. From an Oslerian clinicopathological perspective, the wide complexity of PD converges into Lewy bodies and ... -
Biomarkers in Hepatocellular Carcinoma: Diagnosis, Prognosis and Treatment Response Assessment
(2020-06)Abstract Hepatocellular carcinoma (HCC) is one of the main cancer-related causes of death worldwide. Thus, there is a constant search for improvement in screening, diagnosis, and treatment strategies to improve the prognosis ... -
Características de las residencias de terapia intensiva pediátrica de la República Argentina. Encuesta nacional
(Arch Argent Pediatr., 2015-10-01)INTRODUCTION: Pediatric intensive care residency programs have been in place in Argentina for just a few years. Knowing their status offers the possibility to establish strategies to help with professional development and ... -
Cell Death Mechanisms in Human Chronic Liver Diseases: A Far Cry From Clinical Applicability
(Portland Press, 2016-10-20)The liver is constantly exposed to a host of injurious stimuli. This results in hepatocellular death mainly by apoptosis and necrosis, but also due to autophagy, necroptosis, pyroptosis and in some cases by an intricately ... -
Children admitted to PICU after hematopoietic stem cell transplantation: A predictive model of mortality.
(Torres et al., 2019-08-16)Abstract Introduction: Hematopoietic stem cell transplantation (HSCT) in children is associated with severe complications that need admission to critical care units. Mortality in this group of patients remains high with ... -
Chronic hepatitis C and chronic kidney disease: Advances, limitations and unchartered territories
(Wiley, 2017-01-20)Over the past few years, treatment options for chronic hepatitis C virus (HCV) infection have evolved dramatically. The current approved interferon-free direct-acting antiviral (DAA) regimens have been shown to be safe and ... -
Chronic hepatitis C and chronic kidney disease: Advances, limitations and unchartered territories.
(Wiley, 2017-06-01)Over the past few years, treatment options for chronic hepatitis C virus (HCV) infection have evolved dramatically. The current approved interferon-free direct-acting antiviral (DAA) regimens have been shown to be safe and ... -
Chronic hyperprolactinemia evoked by disruption of lactotrope dopamine D2 receptors impacts on liver and adipocyte genes related to glucose and insulin balance.
(American Physiological Society, 2016-11-01)We studied the impact of high prolactin titers on liver and adipocyte gene expression related to glucose and insulin homeostasis in correlation with obesity onset. To that end we used mutant female mice that selectively ... -
Clinical epidemiology of acute hepatitis C in South America.
(Wiley, 2016-06)There is scarce data pertaining to acute hepatitis C (aHC) infection in South America. We aimed to describe clinical characteristics and evolution of aHC in a South American cohort. A retrospective survey was conducted at ... -
Combined rasagiline and antidepressant use in Parkinson disease in the ADAGIO study: effects on nonmotor symptoms and tolerability.
(JAMA Neurology, 2015-01-01)IMPORTANCE: Depression, cognitive impairment, and other nonmotor symptoms (NMSs) are common early in Parkinson disease (PD) and may be in part due to disease-related dopamine deficiency. Many patients with PD are treated ... -
A Comprensive study of epigenetic alterations in hepatocellular carcicoma identifies potencial therapeutic targets.
(Elsevier B.V. All rights reserved, 2019-07-01)Abstract Background & aims: A causal link has recently been established between epigenetic alterations and hepatocarcinogenesis, indicating that epigenetic inhibition may have therapeutic potential. We aimed to identify ... -
Considerations about the infant safe sleep: Executive summary
(Arch Argent Pediatr., 2015-06-01)Arch Argent Pediatr. 2015 Jun;113(3):285-7. doi: 10.5546/aap.2015.285. [Considerations about the infant safe sleep: Executive summary]. [Article in Spanish] Grupo de Trabajo en Muerte Súbita e Inesperada del Lactante, ... -
Corneal Neovascularization: A Combined Approach of Bevacizumab and Suramin Showed Increased Antiangiogenic Effect Through Downregulation of BFGF and P2X2
(Current Eye Research, 2017-12-21)ABSTRACT Purpose: The objective is to analyze the antiangiogenic mechanism of suramab, a pharmaceutical compound of bevacizumab and suramin, in a rabbit model of corneal angiogenesis. Material and Methods: Corneal ... -
Cross-Cultural Adaptation and Psychometric Evaluation of a Second Victim Experience and Support Tool (SVEST)
(Wolters Kluwer Health, Inc., 2018-05-03)Abstract Introduction: The second victim is defined as the health professionals who commit an error and are traumatized by the event manifesting psychological, cognitive, and/or physical reactions that have a personal ...