Browsing Investigación básica. by Title
Now showing items 50-69 of 79
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Development of an Improved Guanidine-Based Rac1 Inhibitor with in vivo Activity against Non-Small Cell Lung Cancer
(Wiley, 2021-03)Abstract The Rho GTPase Rac1 is involved in the control of cytoskeleton reorganization and other fundamental cellular functions. Aberrant activity of Rac1 and its regulators is common in human cancer. In particular, ... -
Diverse cellular origins of adult blood vascular endothelial cells
(Elsevier, 2021-09)Abstract During embryonic stages, vascular endothelial cells (ECs) originate from the mesoderm, at specific extraembryonic and embryonic regions, through a process called vasculogenesis. In the adult, EC renewal/replacement ... -
dockECR: Open consensus docking and ranking protocol for virtual screening of small molecules
(Elsevier, 2021-12)Abstract The development of open computational pipelines to accelerate the discovery of treatments for emerging diseases allows finding novel solutions in shorter periods of time. Consensus molecular docking is one of ... -
Evaluation of Silicone Fluids and Resins as CO2 Thickeners for Enhanced Oil Recovery Using a Computational and Experimental Approach
(American Chemical Society [Society Publisher], 2021-09)Abstract CO2 thickeners have the potential to be a game changer for enhanced oil recovery, carbon capture utilization and storage, and hydraulic fracturing. Thickener design is challenging due to polymers' low solubility ... -
Exploring the Relationship between Shared Decision-Making, Patient-Centered Medicine, and Evidence-Based Medicine
(SAGE Publications, 2021-08)Abstract Shared decision-making is a possible link between the best of patient-centered medicine and evidence-based medicine. This article seeks to describe the link between them. It discusses to what extent the integration ... -
Feeding difficulties in children and adolescents with spinal muscular atrophy type 2
(Elsevier, 2021-02)Abstract Disease course of feeding difficulties in spinal muscular atrophy type 2 is not well documented. Disease-modifying therapies rapidly change the trajectory of motor function and survival in spinal muscular atrophy, ... -
Functional anatomy of idiomatic expressions
(Springer, 2021-07)Abstract Idiomatic expressions (IE) are groups of words whose meaning is different from the sum of its components. Neural mechanisms underlying their processing are still debated, especially regarding lateralization, main ... -
Functional and druggability analysis of the SARS-CoV-2 proteome
(Elsevier, 2021-01)Abstract The infectious coronavirus disease (COVID-19) pandemic, caused by the coronavirus SARS-CoV-2, appeared in December 2019 in Wuhan, China, and has spread worldwide. As of today, more than 46 million people have ... -
GABAergic Mechanisms Can Redress the Tilted Balance between Excitation and Inhibition in Damaged Spinal Networks
(Springer, 2021-08)Abstract Correct operation of neuronal networks depends on the interplay between synaptic excitation and inhibition processes leading to a dynamic state termed balanced network. In the spinal cord, balanced network activity ... -
Hepatokines and adipokines in NASH-related hepatocellular carcinoma
(Elsevier, 2021-02)Abstract The incidence of hepatocellular carcinoma (HCC) is increasing in industrialised societies; this is likely secondary to the increasing burden of non-alcoholic fatty liver disease (NAFLD), its progressive form ... -
HERC1 Regulates Breast Cancer Cells Migration and Invasion
(MDPI, 2021-03)Abstract Tumor cell migration Tumor cell migration and invasion into adjacent tissues is one of the hallmarks of cancer and the first step towards secondary tumors formation, which represents the leading cause of ... -
[Idursulfase desensitization in a child with Hunter syndrome (mucopolysaccharidosis II)]
(sociedad argentina de pediatria, 2021-02)Abstract in English, Spanish Enzyme replacement therapy with idursulfase decreases morbidity and improves quality of life of patients with mucopolysaccharidosis ii. Immediate hypersensitivity reactions to this drug have ... -
Immunotherapy for Hepatocellular Carcinoma: Is Latin America Ready for Primetime?
(AASLD, 2020-09)Potential conflict of interest: Nothing to report. Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer‐related death worldwide, and its mortality is increasing steadily.1 HCC incidence has grown in the ... -
IMT504 Provides Analgesia by Modulating Cell Infiltrate and Inflammatory Milieu in a Chronic Pain Model
(Springer [Commercial Publisher], 2021-09)Abstract IMT504 is a non-CPG, non-coding synthetic oligodeoxinucleotide (ODN) with immunomodulatory properties and a novel inhibitory role in pain transmission, exerting long-lasting analgesic effects upon multiple systemic ... -
Intrathecal Administration of an Anti-nociceptive Non-CpG Oligodeoxynucleotide Reduces Glial Activation and Central Sensitization
(Springer, 2021-12)Abstract Inflammatory pain associates with spinal glial activation and central sensitization. Systemic administration of IMT504, a non-CpG oligodeoxynucleotide originally designed as an immunomodulator, exerts remarkable ... -
Limitation of life-sustaining treatment in NICU: Physicians' beliefs and attitudes in the Buenos Aires region
(Elsevier, 2020-03)Abstract Objective: To explore the ethical beliefs and attitudes of Argentinean neonatologists regarding limitation of life-sustaining treatment (LST) for very sick infants. Methods: We used an anonymous questionnaire ... -
Multiprong control of glioblastoma multiforme invasiveness: blockade of pro-inflammatory signaling, anti-angiogenesis, and homeostasis restoration
(Springer, 2021-09)Abstract Glioblastoma multiforme (GBM) is the most invasive type of glial tumor with poor overall survival, despite advances in surgical resection, chemotherapy, and radiation. One of the main challenges in treating GBM ... -
New insights into oxidative stress and immune mechanisms involved in age-related macular degeneration tackled by novel therapies
(Elsevier, 2021-05)Abstract The prevalence of age-related macular degeneration (AMD) has increased in the last years. Although anti-VEGF agents have improved the prognosis of exudative AMD, dry AMD has still devastating effects on elderly ... -
Nicotine Neurotoxicity Involves Low Wnt1 Signaling in Spinal Locomotor Networks of the Postnatal Rodent Spinal Cord
(MDPI, 2021-09)Abstract The postnatal rodent spinal cord in-vitro is a useful model to investigate early pathophysiological changes after injury. While low dose nicotine (1 µM) induces neuroprotection, how higher doses affect spinal ... -
Optical clearing reveals TNBS-induced morphological changes of VGLUT2-positive nerve fibers in mouse colorectum
(American Physiological Society, 2021-04)Abstract Colorectal hypersensitivity and sensitization of both mechanosensitive and mechanically insensitive afferents develop after intracolonic instillation of 2,4,6-trinitrobenzenesulfonic acid (TNBS) in the mouse, a ...