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Prevalencia de prescripción potencialmente inapropiada de medicamentos en adultos mayores
(Elsevier España, 2016-03-10)
Introducción: Una de las causas prevenibles de los eventos adversos a medicamentos (EAM) en
los adultos mayores lo constituye la prescripción inapropiada (PIM), es decir, aquella prescripción donde los riesgos superan los ...
Investigación con pacientes en cuidados paliativos: dilemas éticos y percepción pública sobre su vulnerabilidad. Estudio exploratorio
(Universidad de La Sabana, 2016-07-01)
Los pacientes con enfermedades oncológicas en cuidados paliativos pertenecen a un grupo caracterizado como altamente vulnerable y su inclusión en estudios clínicos presenta diversos problemas éticos. Estudio de corte ...
Investigación con pacientes en cuidados paliativos: dilemas éticos y percepción pública sobre su vulnerabilidad. Estudio exploratorio
(Universidad de La Sabana, 2016)
Los pacientes con enfermedades oncológicas en cuidados paliativos pertenecen a un grupo caracterizado como altamente vulnerable y su inclusión en estudios clínicos presenta diversos problemas éticos. Estudio de corte ...
Chronic hyperprolactinemia evoked by disruption of lactotrope dopamine D2 receptors impacts on liver and adipocyte genes related to glucose and insulin balance.
(American Physiological Society, 2016-11-01)
We studied the impact of high prolactin titers on liver and adipocyte gene expression related to glucose and insulin homeostasis in correlation with obesity onset. To that end we used mutant female mice that selectively ...
Dorsal root ganglion neurons and tyrosine hydroxylase--an intriguing association with implications for sensation and pain.
(International Association for the Study of Pain, 2016-02-01)
Tyrosine hydroxylase (TH) is a rate-limiting enzyme broadly expressed in noradrenergic and
dopaminergic neurons in the central nervous system [57,70]. TH is also expressed by peripheral
sympathetic neurons [98] as well ...
Supporting Families After Traumatic Brain Injury, Is This a Way of Improving Results?
(Lippincott, Williams & Wilkins, 2016-07-01)
Supporting Families After Traumatic Brain Injury, Is This a Way of Improving Results?
Treatment of Fabry's Disease with the Pharmacologic Chaperone Migalastat.
(Massachusetts Medical Society, 2016-08-11)
BACKGROUND:
Fabry's disease, an X-linked disorder of lysosomal α-galactosidase deficiency, leads to substrate accumulation in multiple organs. Migalastat, an oral pharmacologic chaperone, stabilizes specific mutant forms ...
Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1: phenotype and genotype correlations in 71 patients.
(John Wiley & Sons, Inc. All rights reserved, 2016-03-01)
BACKGROUND:
The encephalomyopathic mtDNA depletion syndrome with methylmalonic aciduria is associated with deficiency of succinate-CoA ligase, caused by mutations in SUCLA2 or SUCLG1. We report here 25 new patients with ...
International variations in application of the best-interest standard across the age spectrum.
(Springer Nature [academic journals on nature.com, 2016-10-13)
OBJECTIVE:
Ethically and legally, assertions that resuscitation is in a patient's best interest should be inversely correlated with willingness to forego intensive care (and accept comfort care) at the surrogate's request. ...
Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration
(Elsevier B.V. ScienceDirect, 2016-04-01)
Oxidative stress has a critical role in the pathogenesis of Age-related Macular Degeneration (AMD), a
multifactorial disease that includes age, gene variants of complement regulatory proteins and smoking as
the main risk ...