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A few challenges in mucopolysaccharidosis type I
(2021-06-01)
RESUMEN
Se describen como desafíos actuales en
mucopolisacaridosis I la necesidad de una
clasificación adecuada, vinculándola a las
indicaciones terapéuticas; el diagnóstico
temprano desde la pesquisa neonatal, ...
[Idursulfase desensitization in a child with Hunter syndrome (mucopolysaccharidosis II)]
(sociedad argentina de pediatria, 2021-02)
Abstract in English, Spanish
Enzyme replacement therapy with idursulfase decreases morbidity and improves quality of life of patients with mucopolysaccharidosis ii. Immediate hypersensitivity reactions to this drug have ...
HERC1 Regulates Breast Cancer Cells Migration and Invasion
(MDPI, 2021-03)
Abstract
Tumor cell migration
Tumor cell migration and invasion into adjacent tissues is one of the hallmarks of cancer and the first step towards secondary tumors formation, which represents the leading cause of ...
Argentine Consensus of the Diagnosis and Treatment of Hereditary Angioedema
(Revista alergia mexico, 2021-07)
Abstract in English, Spanish
Objectives: Hereditary angioedema (HAE) is a rare disease. During the last years, many studies and advances have been developed with the aim of better understanding the pathophysiology, as ...
Artificial intelligence in the early stages of drug discovery
(Elsevier, 2021-02)
Abstract
Although the use of computational methods within the pharmaceutical industry is well established, there is an urgent need for new approaches that can improve and optimize the pipeline of drug discovery and ...
USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer
(Springer Nature, 2021-03)
Abstract
Tumor cell dissemination in cancer patients is associated with a significant reduction in their survival and quality of life. The ubiquitination pathway plays a fundamental role in the maintenance of protein ...
Combination of pose and rank consensus in docking-based virtual screening: the best of both worlds
(Royal Society of Chemistry, 2021-11)
Abstract
The use of high-throughput docking (HTD) in the drug discovery pipeline is today widely established. In spite of methodological improvements in docking accuracy (pose prediction), scoring power, ranking power, ...
Corynebacterium kroppenstedtii breast infections: Report of four cases
(Elsevier, 2021-10)
Abstract
Corynebacterium kroppenstedtii is an immobile, non-sporulated, glucose-fermenting and lipophilic gram-positive rod of the skin microbiota. In recent years, numerous isolates of this species have been reported ...
Hepatokines and adipokines in NASH-related hepatocellular carcinoma
(Elsevier, 2021-02)
Abstract
The incidence of hepatocellular carcinoma (HCC) is increasing in industrialised societies; this is likely secondary to the increasing burden of non-alcoholic fatty liver disease (NAFLD), its progressive form ...
Acceleration of TAA-Induced Liver Fibrosis by Stress Exposure Is Associated with Upregulation of Nerve Growth Factor and Glycopattern Deviations
(MDPI [Commercial Publisher], 2021-05-01)
Abstract
Liver fibrosis results from many chronic injuries and may often progress to cirrhosis and hepatocellular carcinoma (HCC). In fact, up to 90% of HCC arise in a cirrhotic liver. Conversely, stress is implicated in ...