Browsing Investigación Aplicada by Author "Marquioni-Ramella, Melisa D."
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Early ciliary and prominin-1 dysfunctions precede neurogenesis impairment in a mouse model of type 2 diabetes.
Bachor, Tomás P.; Karbanová, Jana.; Büttner, Edgar.; Bermúdez, Vicente.; Marquioni-Ramella, Melisa D.; Carmeliet, Peter.; Corbeil, Denis.; Suburo, Angela. (Elsevier Inc. All rights reserved., 2017-12-01)Diabetes mellitus (DM) is reaching epidemic conditions worldwide and increases the risk for cognition impairment and dementia. Here, we postulated that progenitors in adult neurogenic niches might be particularly vulnerable. ... -
Glucocorticoid and progesterone mechanisms in photoreceptor survival
Marquioni-Ramella, Melisa D.; Cubilla, Marisa.; Bermúdez, Vicente.; Tate, Pablo.; Marazita, Mariela.; Suburo, Angela. (Elsevier B.V. ScienceDirect, 2020-01-01)Abstract Death of retinal photoreceptors is the basis of prevalent blinding diseases. Since steroids might have a therapeutic role in retinal degenerations, we compared the protective effects of dexamethasone and progesterone ... -
Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells
Tate, Pablo.; Marazita, Mariela.; Marquioni-Ramella, Melisa D.; Suburo, Angela. (Elsevier Ltd. All rights reserved, 2020-04-01)Abstract Aged-related macular degeneration (AMD), a prevalent chronic disease leading to blindness, is associated with oxidative damage of the retinal pigment epithelium (RPE). Ilex paraguariensis (yerba mate, YM), widely ... -
Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration
Marazita, Mariela.; Dugour, Andrea; Marquioni-Ramella, Melisa D.; Figueroa, Juan M.; Suburo, Angela. (Elsevier B.V. ScienceDirect, 2016-04-01)Oxidative stress has a critical role in the pathogenesis of Age-related Macular Degeneration (AMD), a multifactorial disease that includes age, gene variants of complement regulatory proteins and smoking as the main risk ...