Browsing Investigación Aplicada by Author "Marazita, Mariela."
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Glucocorticoid and progesterone mechanisms in photoreceptor survival
Marquioni-Ramella, Melisa D.; Cubilla, Marisa.; Bermúdez, Vicente.; Tate, Pablo.; Marazita, Mariela.; Suburo, Angela. (Elsevier B.V. ScienceDirect, 2020-01-01)Abstract Death of retinal photoreceptors is the basis of prevalent blinding diseases. Since steroids might have a therapeutic role in retinal degenerations, we compared the protective effects of dexamethasone and progesterone ... -
Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells
Tate, Pablo.; Marazita, Mariela.; Marquioni-Ramella, Melisa D.; Suburo, Angela. (Elsevier Ltd. All rights reserved, 2020-04-01)Abstract Aged-related macular degeneration (AMD), a prevalent chronic disease leading to blindness, is associated with oxidative damage of the retinal pigment epithelium (RPE). Ilex paraguariensis (yerba mate, YM), widely ... -
Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration
Marazita, Mariela.; Dugour, Andrea; Marquioni-Ramella, Melisa D.; Figueroa, Juan M.; Suburo, Angela. (Elsevier B.V. ScienceDirect, 2016-04-01)Oxidative stress has a critical role in the pathogenesis of Age-related Macular Degeneration (AMD), a multifactorial disease that includes age, gene variants of complement regulatory proteins and smoking as the main risk ...