Browsing Investigación Aplicada by Author "Lopez, Emiliano S."
Now showing items 1-5 of 5
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Corneal Neovascularization: A Combined Approach of Bevacizumab and Suramin Showed Increased Antiangiogenic Effect Through Downregulation of BFGF and P2X2
Lopez, Emiliano S.; Ortiz, Gustavo.; Potilinski, Constanza.; Croxatto, Oscar.; Gallo, Juan E. (Current Eye Research, 2017-12-21)ABSTRACT Purpose: The objective is to analyze the antiangiogenic mechanism of suramab, a pharmaceutical compound of bevacizumab and suramin, in a rabbit model of corneal angiogenesis. Material and Methods: Corneal ... -
Elucidating the mechanism of action of alpha-1-antitrypsin using retinal pigment epithelium cells exposed to high glucose. Potential use in diabetic retinopathy
Potilinski, María.; Ortiz, Gustavo.; Salica, Juan.; Lopez, Emiliano S.; Fernandez, Mariano.; Chuluyan, Eduardo.; Gallo, Juan E. (Potilinski et a, 2020-02-07)Abstract Background: Alpha-1-antitrypsin is a protein involved in avoidance of different processes that are seen in diabetic retinopathy pathogenesis. These processes include apoptosis, extracellular matrix remodeling and ... -
Evaluation of the Performance of an Ophthalmic Thermosensitive Hydrogel Containing Combination of Suramin and Bevacizumab.
Quinteros, Daniela A.; Lopez, Emiliano S.; Couto, Juan L.; Maletto, Belkys A.; Allemandi, Daniel A.; Palma, Santiago D.; Gallo, Juan E. (Bentham Science Publishers, 2016)Suramab (SUM) is a new pharmaceutical combination made up of suramine (SUR) and bevacizumab (BVM), which showed a high synergistic effect when administered jointly. As the pharmaceutical vehicle, poloxamer aqueous dispersions ... -
Evaluation of the Performance of an Ophthalmic Thermosensitive Hydrogel Containing Combination of Suramin and Bevacizumab.
Quinteros, Daniela.; Lopez, Emiliano S.; Couto, Juan L.; Maletto, Belkys A.; Allemandi, Daniel A.; Palma, Santiago D.; Gallo, Juan E. (Bentham Science Publishers, 2016)Suramab (SUM) is a new pharmaceutical combination made up of suramine (SUR) and bevacizumab (BVM), which showed a high synergistic effect when administered jointly. As the pharmaceutical vehicle, poloxamer aqueous dispersions ... -
Possible neuroprotective role of P2X2 in the retina of diabetic rats.
Mancini, Jorge.; Ortiz, Gustavo.; Potilinski, Constanza.; Salica, Juan.; Lopez, Emiliano S.; Croxatto, Oscar.; Gallo, Juan E. (Springer Nature, 2018-04-12)Abstract Background: Purinergic receptors are expressed in diferent tissues including the retina. These receptors are involved in processes like cell growth, proliferation, activation and survival. ATP is the major ...