Search
Now showing items 1-10 of 76
A familiar study on self-limited childhood epilepsy patients using hIPSC-derived neurons shows a bias towards immaturity at the morphological, electrophysiological and gene expression levels
(BMC, 2021-11-01)
Background: Self-limited Childhood Epilepsies are the most prevalent epileptic syndrome in children. Its pathogenesis is unknown. In this disease, symptoms resolve spontaneously in approximately 50% of patients when maturity ...
4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice
(Nature Research, 2021-03-01)
Hepatocellular carcinoma (HCC) arises in the setting of advanced liver fibrosis, a dynamic and complex inflammatory disease. The tumor microenvironment (TME) is a mixture of cellular components including cancer cells, ...
A Machine Learning Model to Predict Drug Transfer Across the Human Placenta Barrier
(Frontiers Media, 2021-07-01)
Abstract
The development of computational models for assessing the transfer of chemicals across the placental membrane would be of the utmost importance in drug discovery campaigns, in order to develop safe therapeutic ...
[A functional platform to monitor SARS-CoV-2-specific T cell responses in vaccinated individuals and COVID-19 recovered patients]
(Medicina Buenos Aires, 2021-07-01)
Abstract in English, Spanish
The rapid spread of the SARS-CoV-2, the causative agent of the emergent pandemic disease COVID-19, requires the urgent commitment of the immunology community to understand the adaptive immune ...
A few challenges in mucopolysaccharidosis type I
(2021-06-01)
RESUMEN
Se describen como desafíos actuales en
mucopolisacaridosis I la necesidad de una
clasificación adecuada, vinculándola a las
indicaciones terapéuticas; el diagnóstico
temprano desde la pesquisa neonatal, ...
A poor and delayed anti-SARS-CoV2 IgG response is associated to severe COVID-19 in children
(Elsevier, 2021-10-01)
Abstract
Background: Most children and youth develop mild or asymptomatic disease during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, a very small number of patients suffer severe ...
Acute peritoneal dialysis, complications and outcomes in 389 children with STEC-HUS: a multicenter experience
(Springer [Commercial Publisher], 2021-06-01)
Abstract
Background: Management of acute kidney injury (AKI) in children with hemolytic uremic syndrome induced by a Shiga toxin-producing Escherichia coli infection (STEC-HUS) is supportive; however, 40 to 60% of cases ...
A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia
(Massachusetts Medical Society [Society Publisher], 2021-02-01)
Abstract
Background: Convalescent plasma is frequently administered to patients with Covid-19 and has been reported, largely on the basis of observational data, to improve clinical outcomes. Minimal data are available ...
A Year of Living Dangerously: Challenges and Recommendations for Safely Performing Ophthalmic Surgery During the COVID-19 Pandemic, from Start to Finish
(Taylor and Francis Group [Commercial Publisher] Dove Press [Imprint], 2021-01-15)
Abstract
The COVID-19 pandemic has forced all nations to take an active role in infection control incorporating recommendations and measures to control viral dissemination. The epidemiological impact is very diverse and ...
Functional and druggability analysis of the SARS-CoV-2 proteome
(Elsevier, 2021-01)
Abstract
The infectious coronavirus disease (COVID-19) pandemic, caused by the coronavirus SARS-CoV-2, appeared in December 2019 in Wuhan, China, and has spread worldwide. As of today, more than 46 million people have ...