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International study on the outcome of locoregional therapy for liver transplant in hepatocellular carcinoma beyond Milan criteria
(Elsevier, 2021-07)
Abstract
Background & aims: Good outcomes after liver transplantation (LT) have been reported after successfully downstaging to Milan criteria in more advanced hepatocellular carcinoma (HCC). We aimed to compare post-LT ...
Exploring the Relationship between Shared Decision-Making, Patient-Centered Medicine, and Evidence-Based Medicine
(SAGE Publications, 2021-08)
Abstract
Shared decision-making is a possible link between the best of patient-centered medicine and evidence-based medicine. This article seeks to describe the link between them. It discusses to what extent the integration ...
4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice
(Nature Research, 2021-03-01)
Hepatocellular carcinoma (HCC) arises in the setting of advanced liver fibrosis, a dynamic and complex inflammatory disease. The tumor microenvironment (TME) is a mixture of cellular components including cancer cells, ...
Bioinformatic analysis of RHO family of GTPases identifies RAC1 pharmacological inhibition as a new therapeutic strategy for hepatocellular carcinoma
(BMJ Publishing Group, 2021-07)
Abstract
Objective: The RHO family of GTPases, particularly RAC1, has been linked with hepatocarcinogenesis, suggesting that their inhibition might be a rational therapeutic approach. We aimed to identify and target ...
Practice-Changing Use of the 21-Gene Test for the Management of Patients With Early-Stage Breast Cancer in Latin America
(American Society of Clinical Oncology, 2021-08)
Abstract
Purpose: We present a physician survey of the impact of 21-gene Breast Recurrence Score test results on treatment decisions in clinical practice in Latin America.
Methods: This prospective survey enrolled ...
New recommendations for the care of patients with mucopolysaccharidosis type I
(Sociedad argentina de pediatría, 2021-04)
Abstract in English, Spanish
Considering the advances made on mucopolysaccharidosis type I after the consensus study published by a group of experts in Argentina in 2008, recommendations about genetic testing, cardiological ...
Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury
(Frontiers Media, 2021-10)
Abstract
Spinal Cord Injury (SCI) can elicit a progressive loss of nerve cells promoting disability, morbidity, and even mortality. Despite different triggering mechanisms, a cascade of molecular events involving complex ...
15. Diabetes Care in the Hospital: Standards of Medical Care in Diabetes-2021
(Diabetes Care, 2021-01-01)
The American Diabetes Association (ADA) "Standards of Medical Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment ...