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dc.contributor.authorTate, Pablo.
dc.contributor.authorMarazita, Mariela.
dc.contributor.authorMarquioni-Ramella, Melisa D.
dc.contributor.authorSuburo, Angela.
dc.date.accessioned2020-10-01T22:00:13Z
dc.date.available2020-10-01T22:00:13Z
dc.date.issued2020-04-01
dc.identifier.citationJournal of Functional Foods Volume 67, April 2020, 103833en_US
dc.identifier.issn1756-4646
dc.identifier.urihttps://riu.austral.edu.ar/handle/123456789/974
dc.descriptionOpen Access https://www.sciencedirect.com/science/article/pii/S1756464620300578en_US
dc.description.abstractAbstract Aged-related macular degeneration (AMD), a prevalent chronic disease leading to blindness, is associated with oxidative damage of the retinal pigment epithelium (RPE). Ilex paraguariensis (yerba mate, YM), widely consumed in South America, is an excellent source of antioxidants and could prevent RPE cell impairment. Therefore, we evaluated the effects of YM extracts or caffeic (CAF) and chlorogenic (CHL) acids, two major Ilex polyphenols on cell death or premature senescence in a cell line derived from human RPE (ARPE-19). Cultures were incubated with YM, CAF, CHL or appropriate controls and then exposed to H2O2. Protection was correlated with decreases of reactive oxygen species (ROS) and DNA breaks, phosphorylation of the cAMP response element (CREB) and increases of the nuclear factor erythroid 2-related factor 2 (NRF2), BCL2, superoxide dismutase (SOD2) and sirtuin 1 (SIRT1). These results support the protective role of YM and its polyphenols against oxidative stress induced RPE injury.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd. All rights reserveden_US
dc.subjectIlex paraguariensisen_US
dc.subjectMacular degenerationen_US
dc.subjectRetinal pigment epitheliumen_US
dc.titleIlex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cellsen_US
dc.typeArticleen_US


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