Early ciliary and prominin-1 dysfunctions precede neurogenesis impairment in a mouse model of type 2 diabetes.

DSpace/Manakin Repository

Early ciliary and prominin-1 dysfunctions precede neurogenesis impairment in a mouse model of type 2 diabetes.

Show simple item record

dc.contributor.author Bachor, Tomás P.
dc.contributor.author Karbanová, Jana.
dc.contributor.author Büttner, Edgar.
dc.contributor.author Bermúdez, Vicente.
dc.contributor.author Marquioni, Melisa D.
dc.contributor.author Carmeliet, Peter.
dc.contributor.author Corbeil, Denis.
dc.contributor.author Suburo, Angela.
dc.date.accessioned 2020-09-22T15:38:40Z
dc.date.available 2020-09-22T15:38:40Z
dc.date.issued 2017-12-01
dc.identifier.citation Neurobiol Dis 2017 Dec;108:13-28 en_US
dc.identifier.issn 0969-9961
dc.identifier.uri https://riu.austral.edu.ar/handle/123456789/947
dc.description.abstract Diabetes mellitus (DM) is reaching epidemic conditions worldwide and increases the risk for cognition impairment and dementia. Here, we postulated that progenitors in adult neurogenic niches might be particularly vulnerable. Therefore, we evaluated the different components of the mouse subventricular zone (SVZ) during the first week after chemical induction of type 1 and type 2 diabetes-like (T1DM and T2DM) conditions. Surprisingly, only T2DM mice showed SVZ damage. The initial lesions were localized to ependymal cilia, which appeared disorientated and clumped together. In addition, they showed delocalization of the ciliary membrane protein prominin-1. Impairment of neuroprogenitor proliferation, neurogenic marker abnormalities and ectopic migration of neuroblasts were found at a later stage. To our knowledge, our data describe for the first time such an early impact of T2DM on the SVZ. This is consistent with clinical data indicating that brain damage in T2DM patients differs from that in T1DM patients. en_US
dc.language.iso en en_US
dc.publisher Elsevier Inc. All rights reserved. en_US
dc.subject CD133 en_US
dc.subject Diabetes en_US
dc.subject Glucose transporter en_US
dc.subject Neurogenesis en_US
dc.subject Prominin, Subventricular zone en_US
dc.subject Neurodegeneration en_US
dc.title Early ciliary and prominin-1 dysfunctions precede neurogenesis impairment in a mouse model of type 2 diabetes. en_US
dc.type Article en_US


Files in this item

Files Size Format View Description
Neurobiology of ... men 108, Páginas 13-28.pdf 291.2Kb PDF View/Open IA - Suburo

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account