Incidence, risk factors, and outcomes related with neurological events after liver transplantation in adult and pediatric recipients.

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Incidence, risk factors, and outcomes related with neurological events after liver transplantation in adult and pediatric recipients.

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dc.contributor.author Piñero, Federico.
dc.contributor.author Cheang, Yu.
dc.contributor.author Mendizabal, Manuel.
dc.contributor.author Cagliani, Joaquin.
dc.contributor.author Gonzalez, Ariel.
dc.contributor.author Pages, Josefina.
dc.contributor.author Colaci, Carla.
dc.contributor.author et al.
dc.date.accessioned 2020-03-13T18:13:33Z
dc.date.available 2020-03-13T18:13:33Z
dc.date.issued 2018-02-07
dc.identifier.citation Pediatr Transplant. 2018 May;22(3):e13159 en_US
dc.identifier.issn 1397-3142
dc.identifier.uri https://riu.austral.edu.ar/handle/123456789/871
dc.description.abstract Controversy exists whether NE after LT are more frequently observed in children or adults. We aimed to compare the incidence and outcomes for NE after LT in pediatric and adult recipients. A single-center cohort study, including all LT between 2001 and 2013, was performed. Definition of NE included impaired consciousness, delirium, seizures, focal neurologic deficit, visual impairment, or slurred speech. A cohort of 443 consecutive LT recipients was included: 307 adults and 136 children. Cumulative incidence of NE was similar between adults 15% (n = 41) and children 16% (n = 20; P = .73) with a complete neurological recovery in 62% and 95% of the patients, respectively (P < .0001). Adults with NE had significantly lower survival (70% vs 76%; P = .015) with a HR of 2.36; this was similarly observed in children (45% vs 66%; HR 2.05, CI 0.66; 6.34). Independent risk factors for NE in adults were pre-LT ascites, delta sodium, and post-LT hypomagnesemia, whereas in children pre-LT encephalopathy ≥II and serum albumin were associated with NE. Although a similar incidence of NE after LT was observed, children were more likely to achieve neurological recovery. Risk factors for the development of NE are difficult to assess in both populations. en_US
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.subject Adverse events en_US
dc.subject Immunosuppression en_US
dc.subject Nervous system en_US
dc.subject Transplantation en_US
dc.title Incidence, risk factors, and outcomes related with neurological events after liver transplantation in adult and pediatric recipients. en_US
dc.type Article en_US


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