Show simple item record

dc.contributor.authorHita, Alejandro.
dc.contributor.authorBaratta, Sergio.
dc.contributor.authorChejtman, Demian.
dc.contributor.authorBenticuaga, Alejandro.
dc.contributor.authorCostantini, Ricardo.
dc.contributor.authorVaccarino, Guillermo.
dc.contributor.authorDonato, Martin.
dc.date.accessioned2020-03-02T17:14:16Z
dc.date.available2020-03-02T17:14:16Z
dc.date.issued2015-02-01
dc.identifier.citationREVISTA ARGENTINA DE CARDIOLOGÍA / VOL 83 Nº 1 / FEBRERO 2015en_US
dc.identifier.issn0034-7000
dc.identifier.urihttps://riu.austral.edu.ar/handle/123456789/831
dc.description.abstractBackground: In severe symptomatic aortic stenosis (SSAS) altered global longitudinal systolic strain (GLSS) would correlate with changes in myocardial histological architecture and could identify early contractile involvement in patients with preserved ejection fraction (PEF). Objective: The aim of this study was to analyze GLSS, collagen volume (CV), myocyte area (MyAr) and contractile involvement in patients with SSAS and PEF. Methods: Twenty six patients with SSAS and PEF (67±11 years old, 53% male) were included in the study. A preoperative hemodynamic study and an intraoperative endomyocardial biopsy were performed to determine CV and MyAr. Three groups of patients were identified: G1: compensated left ventricular hypertrophy (LVH) without coronary disease (n=8); G2: decompensated LVH without coronary disease (n=7) and G3: decompensated LVH with coronary disease (n=11). GLSS was normalized by stroke volume, meridional end-systolic wall stress (δ) and end-diastolic diameter (EDD). Results: No significant differences in stroke volume, δ and EDD were observed between groups G1, G2 and G3. Differences between groups were observed in: CV (%) (G1: 4.7 ± 1.2, G2: 8.4 ± 1.2, G3: 11.0 ± 3.0; p < 0.01), MyAr (mm2 ) (G1: 328.7 ± 66.2, G2: 376.7 ± 21.9, G3: 385.0 ± 13.0; p = 0.01), LVEDP (mm Hg) (G1: 13.1 ± 1.5, G2: 19.0 ± 3.8, G3: 23.6 ± 5.8; p < 0.01), +dP/dtmax (mm Hg/sec / LVEDP, mm Hg) (G1: 176.4 ± 45.5, G2: 89.6 ± 20.1, G3: 113.1 ± 43.7; p < 0.01), and GLSS (%) (G1: -17.9 ± 4.2, G2: -13.5 ± 2.5, G3: -13.6 ± 3; p = 0.021). GLSS correlated with CV and LVEDP and it evidenced a trend to correlate with a contractility index (+dP/dtmax mm Hg/s / LVEDP, mm Hg). Conclusions: Altered GLSS in patients with SSAS and PEF expresses myocardial structural changes related to increase in CV, which is associated with enhanced LVEDP and probable myocardial contractile failure.en_US
dc.language.isoesen_US
dc.publisherSociedad Argentina de Cardiologíaen_US
dc.subjectSevere Aortic Stenosisen_US
dc.subjectMyocardiumen_US
dc.subjectDoppler Echocardiographyen_US
dc.subjectStrain Rateen_US
dc.subjectMyocardial Biopsyen_US
dc.titleRelación entre el strain rate y la estructura miocárdica en la estenosis aórtica graveen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record