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dc.contributor.authorGomez-Almaguer, D.
dc.contributor.authorVázquez-Mellado, A.
dc.contributor.authorNavarro Cabrera, J.R.
dc.contributor.authorAbello-Polo, V.
dc.contributor.authorMilovic, V.
dc.contributor.authorGarcia, J.
dc.contributor.authorBasquiera, A.
dc.contributor.authoret al.
dc.date.accessioned2020-02-18T18:25:42Z
dc.date.available2020-02-18T18:25:42Z
dc.date.issued2017-01-01
dc.identifier.citationBone Marrow Transplant. 2017 Jan;52(1):41-46.en_US
dc.identifier.issn0268-3369
dc.identifier.urihttps://riu.austral.edu.ar/handle/123456789/810
dc.description.abstractWe studied 298 patients with severe aplastic anaemia (SAA) allografted in four Latin American countries. The source of cells was bone marrow (BM) in 94 patients and PBSCs in 204 patients. Engraftment failed in 8.1% of recipients with no difference between BM and PBSCs (P=0.08). Incidence of acute GvHD (aGvHD) for BM and PBSCs was 30% vs 32% (P=0.18), and for grades III-IV was 2.6% vs 11.6% (P=0.01). Chronic GvHD (cGvHD) between BM and PBSCs was 37% vs 59% (P=0.002) and extensive 5% vs 23.6% (P=0.01). OS was 74% vs 76% for BM vs PBSCs (P=0.95). Event-free survival was superior in patients conditioned with anti-thymocyte globulin (ATG)-based regimens compared with other regimens (79% vs 61%, P=0.001) as excessive secondary graft failure was seen with other regimens (10% vs 26%, P=0.005) respectively. In multivariate analysis, aGvHD II-IV (hazard ratio (HR) 2.50, confidence interval (CI) 1.1-5.6, P=0.02) and aGvHD III-IV (HR 8.3 CI 3.4-20.2, P<0.001) proved to be independent negative predictors of survival. In conclusion, BM as a source of cells and ATG-based regimens should be standard because of higher GvHD incidence with PBSCs, although the latter combining with ATG in the conditioning regimen could be an option in selected high-risk patients.en_US
dc.language.isoenen_US
dc.publisherSpringer Nature [academic journals on nature.com]en_US
dc.subjectAnemia, Aplastic/mortalityen_US
dc.subjectLatin Americaen_US
dc.subjectStem Cell Transplantation*en_US
dc.titleThe Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplantsen_US
dc.typeArticleen_US


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