Clinical epidemiology of acute hepatitis C in South America.

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Clinical epidemiology of acute hepatitis C in South America.

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dc.contributor.author Dirchwolf, Melisa.
dc.contributor.author Marciano, Sebastián.
dc.contributor.author Mauro, Ezequiel.
dc.contributor.author Ruf, Andres.
dc.contributor.author Rezzonico, Lucrecia.
dc.contributor.author Anders, Margarita.
dc.contributor.author Chiodi, Daniela.
dc.contributor.author et al.
dc.date.accessioned 2020-02-17T19:35:27Z
dc.date.available 2020-02-17T19:35:27Z
dc.date.issued 2016-06
dc.identifier.citation J Med Virol. 2017 Feb;89(2):276-283. en_US
dc.identifier.issn 0146-6615
dc.identifier.uri https://riu.austral.edu.ar/handle/123456789/806
dc.description.abstract There is scarce data pertaining to acute hepatitis C (aHC) infection in South America. We aimed to describe clinical characteristics and evolution of aHC in a South American cohort. A retrospective survey was conducted at 13 hepatology units. All patients ≥16 years old with aHC diagnosis were included. Demographic, clinical and outcome information were registered in a standardized ad hoc questionnaire. Sixty-four patients were included. The majority were middle-aged (median age: 46 years) and female (65.6%); most of them were symptomatic at diagnosis (79.6%). HCV-1 was the most prevalent genotype (69.2%). Five patients had liver failure: three cases of severe acute hepatitis, one case of fulminant hepatitis and one case of acute-on-chronic liver failure. Nosocomial exposure was the most prevalent risk factor. Evolution was assessed in 46 patients. In the untreated cohort, spontaneous resolution occurred in 45.8% and was associated with higher values of AST/ALT and with the absence of intermittent HCV RNA viremia (P = 0.01, 0.05, and 0.01, respectively). In the treated cohort, sustained virological response was associated with nosocomial transmission and early treatment initiation (P = 0.04 each). The prevalence of nosocomial transmission in this South-American cohort of aHC stresses the importance of following universal precautions to prevent HCV infection. J. Med. Virol. 89:276-283, 2017. en_US
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.subject Latin America en_US
dc.subject Epidemiology en_US
dc.subject Hepatitis C virus en_US
dc.subject Nosocomial transmission en_US
dc.title Clinical epidemiology of acute hepatitis C in South America. en_US
dc.type Article en_US


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