Vulvar Langerhans cell histiocytosis and thalidomide: an effective treatment option

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Vulvar Langerhans cell histiocytosis and thalidomide: an effective treatment option

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dc.contributor.author Ruiz, Begueire J.
dc.contributor.author Fernández, Julia
dc.contributor.author Stringa, Matias.
dc.contributor.author Anaya, Javier.
dc.date.accessioned 2020-02-14T18:15:59Z
dc.date.available 2020-02-14T18:15:59Z
dc.date.issued 2017-10-25
dc.identifier.citation Int J Dermatol. 2017 Mar;56(3):324-326. en_US
dc.identifier.issn 0011-9059
dc.identifier.uri https://riu.austral.edu.ar/handle/123456789/798
dc.description.abstract Langerhans cell histiocytosis (LCH) is a disease characterized by clonal proliferation and a pathological infiltration of Langerhans cells in one or more organs, in which almost every tissue may be involved. Its incidence is slightly increased in males.1,2 It is more common in children (only 2% of LCH patients are aged over 70 years), and it may involve multiple systems or may be localized.1 Although it is not a malignancy, LCH may cause the selfdestruction of involved tissues, such as bone, skin, lung, and brain tissue.2,3 Langerhans cell histiocytosis with isolated involvement of the skin or mucous membranes is rare and occurs in only 4–7% of cases.1,2 The occurrence of LCH that is restricted to the vulva is very rare, and fewer than 26 such cases have been published in the literature. We describe a very interesting case in a patient who demonstrated an excellent response to thalidomide. en_US
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.subject Vulvar Diseases/drug therapy en_US
dc.subject Vulvar Diseases/etiology en_US
dc.subject Histiocytosis, Langerhans-Cell/complications en_US
dc.title Vulvar Langerhans cell histiocytosis and thalidomide: an effective treatment option en_US
dc.type Article en_US


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