Cell Death Mechanisms in Human Chronic Liver Diseases: A Far Cry From Clinical Applicability

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Cell Death Mechanisms in Human Chronic Liver Diseases: A Far Cry From Clinical Applicability

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dc.contributor.author Mazzolini, Guillermo.
dc.contributor.author Sowa, Jan-Peter.
dc.contributor.author Canbay, Ali.
dc.date.accessioned 2019-11-19T18:07:43Z
dc.date.available 2019-11-19T18:07:43Z
dc.date.issued 2016-10-20
dc.identifier.citation Clin Sci (Lond) , 130 (23), 2121-2138 en_US
dc.identifier.issn 0143-5221
dc.identifier.uri https://riu.austral.edu.ar/handle/123456789/781
dc.description.abstract The liver is constantly exposed to a host of injurious stimuli. This results in hepatocellular death mainly by apoptosis and necrosis, but also due to autophagy, necroptosis, pyroptosis and in some cases by an intricately balanced combination thereof. Overwhelming and continuous cell death in the liver leads to inflammation, fibrosis, cirrhosis, and eventually hepatocellular carcinoma. Although data from various disease models may suggest a specific (predominant) cell death mode for different aetiologies, the clinical reality is not as clear cut. Reliable and non-invasive cell death markers are not available in general practice and assessment of cell death mode to absolute certainty from liver biopsies does not seem feasible, yet. Various aetiologies probably induce different predominant cell death modes within the liver, although the death modes involved may change during disease progression. Moreover, current methods applicable in patients are limited to surrogate markers for apoptosis (M30), and possibly for pyroptosis (IL-1 family) and necro(pto)sis (HMGB1). Although markers for some death modes are not available at all (autophagy), others may not be specific for a cell death mode or might not always definitely indicate dying cells. Physicians need to take care in asserting the presence of cell death. Still the serum-derived markers are valuable tools to assess severity of chronic liver diseases. This review gives a short overview of known hepatocellular cell death modes in various aetiologies of chronic liver disease. Also the limitations of current knowledge in human settings and utilization of surrogate markers for disease assessment are summarized. en_US
dc.language.iso en en_US
dc.publisher Portland Press en_US
dc.subject Apoptosis en_US
dc.subject Chronic liver disease en_US
dc.subject Necroptosis en_US
dc.subject Necrosis en_US
dc.title Cell Death Mechanisms in Human Chronic Liver Diseases: A Far Cry From Clinical Applicability en_US
dc.type Article en_US


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