Hepatotoxicity Induced by Coxibs: How Concerned Should We Be?

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Hepatotoxicity Induced by Coxibs: How Concerned Should We Be?

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dc.contributor.author Bessone, Fernando.
dc.contributor.author Hernandez, Nelia.
dc.contributor.author Roma, Marcelo.
dc.contributor.author Ridruejo, Ezequiel.
dc.contributor.author Mendizabal, Manuel.
dc.contributor.author et al.
dc.date.accessioned 2019-11-19T17:57:55Z
dc.date.available 2019-11-19T17:57:55Z
dc.date.issued 2016-08-26
dc.identifier.citation Expert Opin Drug Saf , 15 (11), 1463-1475 en_US
dc.identifier.issn 1474-0338
dc.identifier.uri https://riu.austral.edu.ar/handle/123456789/780
dc.description.abstract Introduction: The selective inhibitors of COX-2, coxibs, are nonsteroidal anti-inflammatory drugs (NSAIDs) that have much better gastrointestinal safety profile as compared with non-selective NSAIDs. In this review, we analyze both the epidemiological features of coxib-induced hepatotoxicity and the clinical impact of coxib-associated liver damage, based on literature data. Areas covered: We carried out a search of the databases MEDLINE (PubMed), LILACS and SCIELO, from December 1999 to January 2016, to retrieve studies exploring the real impact of coxibs in liver toxicity as compared to non-selective COX-2 inhibitor NSAIDs. Expert opinion: Although reliable data on the incidence of celecoxib- and etoricoxib-induced hepatotoxicity are lacking, because of cohort studies have been generally underpowered to detect hepatic events, coxibs have been scarcely related to hepatotoxicity. Hence, coxib-induced liver injury seems to be an uncommon event, yet exhibits a wide spectrum of damage. Increasing COX-2 drug selectivity, as for rofecoxib, valdecoxib, parecoxib, and lumiracoxib, has been associated with higher cardiovascular risk, as well as dermatological and serious hepatic reactions. The actual risk of liver toxicity from the currently approved coxibs compared with non-selective NSAIDs will be discussed. Finally, classical and novel molecular mechanisms of coxib-induced hepatotoxicity are also described. en_US
dc.language.iso en en_US
dc.publisher Taylor & Francis en_US
dc.subject Selective COX-2 inhibitors en_US
dc.subject Acute liver failure en_US
dc.subject Cholestasis en_US
dc.subject Coxibs en_US
dc.subject Hepatitis en_US
dc.subject Hepatotoxicity en_US
dc.title Hepatotoxicity Induced by Coxibs: How Concerned Should We Be? en_US
dc.type Article en_US


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