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dc.contributor.authorQuinteros, Daniela A.
dc.contributor.authorLopez, Emiliano S.
dc.contributor.authorCouto, Juan L.
dc.contributor.authorMaletto, Belkys A.
dc.contributor.authorAllemandi, Daniel A.
dc.contributor.authorPalma, Santiago D.
dc.contributor.authorGallo, Juan E.
dc.date.accessioned2019-11-12T19:21:30Z
dc.date.available2019-11-12T19:21:30Z
dc.date.issued2016
dc.identifier.citationCurr Pharm Des. 2016;22(43):6587-6594.en_US
dc.identifier.issn1381-6128
dc.identifier.urihttps://riu.austral.edu.ar/handle/123456789/765
dc.description.abstractSuramab (SUM) is a new pharmaceutical combination made up of suramine (SUR) and bevacizumab (BVM), which showed a high synergistic effect when administered jointly. As the pharmaceutical vehicle, poloxamer aqueous dispersions were used since this system is able to maintain their fluidity at low temperatures (<15ºC) but which become gel in the corporal environment (>35ºC). In the present study we aimed at evaluating the effect of Poloxamer to prolong the effect of SUM. These formulations were characterized using rheological, biopharmaceutical (drug release) and morphological (SEM) technique. Corneal NV was induced in Sprague Dawley rats Corneal. At 15 days of follow up animals were sacrificed and perfused with black drawing ink. Digital photographs were taken and the area of neovascularisation (ANV) was calculated using the image programmed. The rheological behavior was influenced by the addition of drugs, resulting in a decrease in the gelation temperature (Tsol/gel). Both drugs were released from poloxamer gels by means of an anomalous mechanism. However, BVM was released faster than SUR, with their combination (SUM) to appearing to reduce delivery, probably due to interactions between the drugs or with the polymeric matrix. The in vivo studies showed that SUM-poloxamer gel was able to increase the corneal antiangiogenic effect compared to the SUM solution and BVM alone at 15 days of follow-up. Furthermore no injurious effects were observed in the histological tissue examination after drug administration. The presence of Poloxamer, known to modulate control release of biological agents, seems to have a favorable effect on SUM subconjunctival administered.en_US
dc.language.isoenen_US
dc.publisherBentham Science Publishersen_US
dc.subjectThermosensitive hydrogelsen_US
dc.subjectBevacizumaben_US
dc.subjectControlled releaseen_US
dc.subjectNeovascularizationen_US
dc.subjectPoloxameren_US
dc.subjectSuramaben_US
dc.subjectSuramineen_US
dc.titleEvaluation of the Performance of an Ophthalmic Thermosensitive Hydrogel Containing Combination of Suramin and Bevacizumab.en_US
dc.typeArticleen_US


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