The early onset of type 1 autoimmune hepatitis has a strong genetic influence: role of HLA and KIR genes.

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The early onset of type 1 autoimmune hepatitis has a strong genetic influence: role of HLA and KIR genes.

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dc.contributor.author Podhorzer, A.
dc.contributor.author Paladino, N.
dc.contributor.author Cuartero, ML.
dc.contributor.author Fainboim, H.
dc.contributor.author Paz, S.
dc.contributor.author Theiler, G.
dc.contributor.author Capucchio, M.
dc.contributor.author López, S.
dc.contributor.author et al.
dc.date.accessioned 2019-11-11T17:08:23Z
dc.date.available 2019-11-11T17:08:23Z
dc.date.issued 2016-02-18
dc.identifier.citation Genes Immun. 2016 Apr;17(3):187-92. en_US
dc.identifier.issn 1466-4879
dc.identifier.uri https://riu.austral.edu.ar/handle/123456789/754
dc.description.abstract We have previously reported a strong association between HLA-DRB1*1301 and type 1 pediatric autoimmune hepatitis (PAH) and between HLA-DR*0405 and adult autoimmune hepatitis (AAH). Because human killer cell immunoglobulin-like receptors are known to be associated with susceptibility to autoimmune diseases, we investigated the frequencies of HLA-A, B, C, DRB1 and KIR genes in 144 type 1 PAH and 86 AAH patients, which were compared with 273 healthy controls. We demonstrated in PAH the increased frequency of the functional form of KIR2DS4-Full Length (KIR2DS4-FL), which in combination with HLA-DRB1*1301 revealed a strong synergistic effect (odds ratio=36.5). PAH-KIR2DS4-FL+ subjects have shown an increased frequency of their putative HLA-C*02, 04 and 06 ligands. KIR analysis of PAH also revealed a decreased frequency of KIR2DL2 gene and its ligand. In contrast, AAH cases have shown a weaker increased frequency of KIR2DS4-FL, a lack of synergistic effect with HLA class II antigens and a moderate association with HLA-DRB1*0405. Of note, we demonstrated that liver T cells have a unique pattern of KIR expression. These results show a KIR gene involved in autoimmune hepatitis and suggest a stronger genetic influence for the early onset type I autoimmune hepatitis. en_US
dc.language.iso en en_US
dc.publisher Springer Nature Switzerland AG. Springer is part of Springer Nature en_US
dc.subject Hepatitis en_US
dc.subject Autoimmune en_US
dc.subject Genetic influence en_US
dc.title The early onset of type 1 autoimmune hepatitis has a strong genetic influence: role of HLA and KIR genes. en_US
dc.type Article en_US


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