Neuroactive steroids, nociception and neuropathic pain: A flashback to go forward.

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Neuroactive steroids, nociception and neuropathic pain: A flashback to go forward.

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dc.contributor.author Coronel, María F.
dc.contributor.author Labombarda, Florencia.
dc.contributor.author González, Susana.
dc.date.accessioned 2019-11-05T21:41:46Z
dc.date.available 2019-11-05T21:41:46Z
dc.date.issued 2016-04-11
dc.identifier.citation Steroids. 2016 Jun;110:77-87. en_US
dc.identifier.issn 0039-128X
dc.identifier.uri https://riu.austral.edu.ar/handle/123456789/749
dc.description.abstract The present review discusses the potential role of neurosteroids / neuroactive steroids in the regulation of nociceptive and neuropathic pain, and recapitulates the current knowledge on the main mechanisms involved in the reduction of pain, especially those occurring at the dorsal horn of the spinal cord, a crucial site for nociceptive processing. We will make special focus on progesterone and its derivative allopregnanolone, which have been shown to exert remarkable actions in order to prevent or reverse the maladaptive changes and pain behaviors that arise after nervous system damage in various experimental neuropathic conditions. en_US
dc.language.iso en en_US
dc.publisher Elsevier Inc. All rights reserved. en_US
dc.subject Allopregnanolone en_US
dc.subject Chronic pain en_US
dc.subject Neurosteroids en_US
dc.subject Nociceptive pain en_US
dc.subject Progesterone en_US
dc.subject Spinal cord dorsal horn en_US
dc.title Neuroactive steroids, nociception and neuropathic pain: A flashback to go forward. en_US
dc.type Article en_US


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