Investigación Aplicada: Recent submissions
Now showing items 181-200 of 225
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International variations in application of the best-interest standard across the age spectrum.
(Springer Nature [academic journals on nature.com, 2016-10-13)OBJECTIVE: Ethically and legally, assertions that resuscitation is in a patient's best interest should be inversely correlated with willingness to forego intensive care (and accept comfort care) at the surrogate's request. ... -
The Effects of Fat Harvesting and Preparation, Air Exposure, Obesity, and Stem Cell Enrichment on Adipocyte Viability Prior to Graft Transplantation
(Oxford University Press, 2016-07-29)Background: Adipocyte viability is affected by fat preparation and processing methods, but rigorous and objective studies of these relationships are lacking. Objectives: The authors conducted a comprehensive evaluation ... -
Cell Death Mechanisms in Human Chronic Liver Diseases: A Far Cry From Clinical Applicability
(Portland Press, 2016-10-20)The liver is constantly exposed to a host of injurious stimuli. This results in hepatocellular death mainly by apoptosis and necrosis, but also due to autophagy, necroptosis, pyroptosis and in some cases by an intricately ... -
Hepatotoxicity Induced by Coxibs: How Concerned Should We Be?
(Taylor & Francis, 2016-08-26)Introduction: The selective inhibitors of COX-2, coxibs, are nonsteroidal anti-inflammatory drugs (NSAIDs) that have much better gastrointestinal safety profile as compared with non-selective NSAIDs. In this review, we ... -
Systemic Transplantation of Bone Marrow Mononuclear Cells Promotes Axonal Regeneration and Analgesia in a Model of Wallerian Degeneration
(Lippincott, Williams & Wilkins, 2017-07)Background Reinnervation timing after nerve injury is critical for favorable axonal regeneration, remyelination, and clinical improvement. Considering bone marrow mononuclear cells (BMMC) are easily obtained and readily ... -
Hyponatremia and bone disease
(Springer Verlag, 2016-09-24)Hip fractures represent a serious health risk in the elderly, causing substantial morbidity and mortality. There is now a considerable volume of literature suggesting that chronic hyponatremia increases the adjusted odds ... -
De las doctrinas de la lotería de Babilonia a la medicina de precisión en los gliomas
(Elsevier, 2016-07-01)Un trabajo de reciente publicación en Science mostró que algunos tumores son más estocásticos que otros1. Su génesis depende de las reglas de la todopoderosa y astuta Companía ˜ Babilónica, uno de los nombres del azar ... -
Chronic hyperprolactinemia evoked by disruption of lactotrope dopamine D2 receptors impacts on liver and adipocyte genes related to glucose and insulin balance.
(American Physiological Society, 2016-11-01)We studied the impact of high prolactin titers on liver and adipocyte gene expression related to glucose and insulin homeostasis in correlation with obesity onset. To that end we used mutant female mice that selectively ... -
Association Between Cigarette Smoking Prevalence and Income Level: A Systematic Review and Meta-Analysis.
(Oxford University Press, 2017-09)INTRODUCTION: Previous evidence linked low socioeconomic status with higher smoking prevalence. Our objective was to assess the strength of this association in the world population, updating a previous work. METHODS: ... -
Hodgkin lymphoma burden in Central and South America.
(Elsevier, 2016-09)RATIONALE AND OBJECTIVE: Hodgkin lymphoma (HL) is largely curable owing to improvements in treatment since the 1960s; nevertheless, high mortality rates have been reported in Central and South America. We describe the ... -
Uncovering the in vivo source of adult neural crest stem cells
(Mary Ann Liebert, Inc, 2017-03-01)Some late embryonic and adult postmigratory neural crest-derived cells (NCDCs) from diverse tissues were shown to grow as multipotent neurospheres. Neural crest stem cells (NCSCs) contained in these spheres were found to ... -
Ethical dilemmas associated with clinicians' decisions about treatment in critically ill infants born in Córdoba, Argentina.
(SAGE Publications, 2017-01-23)The objective of this article is to examine end of life decisions made by neonatologists of Córdoba, Argentina. An anonymous questionnaire was designed to investigate neonatologists’ decisions on when to initiate or withdraw ... -
South American investigation on professionalism: a theoretical framework.
(John Wiley & Sons Ltd and The Association for the Study of Medical Education, 2016-10-18) -
Investigación con pacientes en cuidados paliativos: dilemas éticos y percepción pública sobre su vulnerabilidad. Estudio exploratorio
(Universidad de La Sabana, 2016)Los pacientes con enfermedades oncológicas en cuidados paliativos pertenecen a un grupo caracterizado como altamente vulnerable y su inclusión en estudios clínicos presenta diversos problemas éticos. Estudio de corte ... -
Investigación con pacientes en cuidados paliativos: dilemas éticos y percepción pública sobre su vulnerabilidad. Estudio exploratorio
(Universidad de La Sabana, 2016-07-01)Los pacientes con enfermedades oncológicas en cuidados paliativos pertenecen a un grupo caracterizado como altamente vulnerable y su inclusión en estudios clínicos presenta diversos problemas éticos. Estudio de corte ... -
Uncovering the in vivo source of adult neural crest stem cells.
(Mary Ann Liebert, 2017-03-01)Some late embryonic and adult postmigratory neural crest-derived cells (NCDCs) from diverse tissues were shown to grow as multipotent neurospheres. Neural crest stem cells (NCSCs) contained in these spheres were found to ... -
Involvement of hepatic macrophages in the antifibrotic effect of IGF-I_overexpressing mesenchymal stromal cells.
(BMC (part of Springer Nature), 2016-11-22)BACKGROUND: Cirrhosis is a major health problem worldwide and new therapies are needed. Hepatic macrophages (hMø) have a pivotal role in liver fibrosis, being able to act in both its promotion and its resolution. It is ... -
Association Between Cigarette Smoking Prevalence and Income Level: A Systematic Review and Meta-Analysis
(Oxford University Press, 2016-10-26)Introduction Previous evidence linked low socioeconomic status with higher smoking prevalence. Our objective was to assess the strength of this association in the world population, updating a previous work. Methods Systematic ... -
Evaluation of the Performance of an Ophthalmic Thermosensitive Hydrogel Containing Combination of Suramin and Bevacizumab.
(Bentham Science Publishers, 2016)Suramab (SUM) is a new pharmaceutical combination made up of suramine (SUR) and bevacizumab (BVM), which showed a high synergistic effect when administered jointly. As the pharmaceutical vehicle, poloxamer aqueous dispersions ... -
La enfermedad renal crónica en la hipertensión arterial y en la enfermedad cardiovascular Chronic Kidney Disease in Hypertension and Cardiovascular Disease.
(Rev Fed Arg Cardiol., 2016-03-29)Chronic kidney disease is frequently present among patients in high cardiovascular risk that are assisted by clinicians and cardiologists. The prevalence of chronic kidney disease among patients with type 2 diabetes mellitus, ...