Browsing Investigación Aplicada by Author "Mazzolini, Guillermo."
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Cell Death Mechanisms in Human Chronic Liver Diseases: A Far Cry From Clinical Applicability
Mazzolini, Guillermo.; Sowa, Jan-Peter.; Canbay, Ali. (Portland Press, 2016-10-20)The liver is constantly exposed to a host of injurious stimuli. This results in hepatocellular death mainly by apoptosis and necrosis, but also due to autophagy, necroptosis, pyroptosis and in some cases by an intricately ... -
Chronic hyperprolactinemia evoked by disruption of lactotrope dopamine D2 receptors impacts on liver and adipocyte genes related to glucose and insulin balance.
Luque, Guillermina.; Lopez-Vicchi, Felicitas.; Ornstein, Ana M.; Brie, Belén.; De Winne, Catalina.; Fiore, Esteban.; Mazzolini, Guillermo.; et al. (American Physiological Society, 2016-11-01)We studied the impact of high prolactin titers on liver and adipocyte gene expression related to glucose and insulin homeostasis in correlation with obesity onset. To that end we used mutant female mice that selectively ... -
A Comprensive study of epigenetic alterations in hepatocellular carcicoma identifies potencial therapeutic targets.
Bayo, Juan.; Esteban, Fiore.; Domínguez, Luciana.; Argemi, Josepmaria.; Martinez, Elizabeth.; Mazzolini, Guillermo. (Elsevier B.V. All rights reserved, 2019-07-01)Abstract Background & aims: A causal link has recently been established between epigenetic alterations and hepatocarcinogenesis, indicating that epigenetic inhibition may have therapeutic potential. We aimed to identify ...