Browsing Investigación Aplicada by Author "Malvicini, Mariana."
Now showing items 1-2 of 2
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Involvement of hepatic macrophages in the antifibrotic effect of IGF-I_overexpressing mesenchymal stromal cells.
Fiore, Esteban.; Malvicini, Mariana.; Bayo, Juan.; Peixoto, Estanislao.; Atorrasagasti, Catalina.; Sierra, Romina.; Rodriguez, Marcelo. (BMC (part of Springer Nature), 2016-11-22)BACKGROUND: Cirrhosis is a major health problem worldwide and new therapies are needed. Hepatic macrophages (hMø) have a pivotal role in liver fibrosis, being able to act in both its promotion and its resolution. It is ... -
SPARC gene deletion protects against toxic liver injury and is associated to an enhanced proliferative capacity and reduced oxidative stress response.
Peixoto, Estanislao; Atorrasagasti, Catalina.; Malvicini, Mariana.; Fiore, Esteban.; Rodriguez, Marcelo.; Garcia, Mariana.; Finocchieto, Paola.; Poderoso, Fernando.; et al. (Oncotarget, 2016-06-25)SPARC, also known as osteonectin and BM-40, is a matricellular protein with a number of biological functions. Hepatic SPARC expression is induced in response to thioacetamide, bile-duct ligation, and acute injuries such ...