Browsing Investigación Aplicada by Issue Date
Now showing items 41-60 of 225
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SPARC gene deletion protects against toxic liver injury and is associated to an enhanced proliferative capacity and reduced oxidative stress response.
(Oncotarget, 2016-06-25)SPARC, also known as osteonectin and BM-40, is a matricellular protein with a number of biological functions. Hepatic SPARC expression is induced in response to thioacetamide, bile-duct ligation, and acute injuries such ... -
Supporting Families After Traumatic Brain Injury, Is This a Way of Improving Results?
(Lippincott, Williams & Wilkins, 2016-07-01)Supporting Families After Traumatic Brain Injury, Is This a Way of Improving Results? -
De las doctrinas de la lotería de Babilonia a la medicina de precisión en los gliomas
(Elsevier, 2016-07-01)Un trabajo de reciente publicación en Science mostró que algunos tumores son más estocásticos que otros1. Su génesis depende de las reglas de la todopoderosa y astuta Companía ˜ Babilónica, uno de los nombres del azar ... -
Investigación con pacientes en cuidados paliativos: dilemas éticos y percepción pública sobre su vulnerabilidad. Estudio exploratorio
(Universidad de La Sabana, 2016-07-01)Los pacientes con enfermedades oncológicas en cuidados paliativos pertenecen a un grupo caracterizado como altamente vulnerable y su inclusión en estudios clínicos presenta diversos problemas éticos. Estudio de corte ... -
A systematic review of faculty development initiatives designed to enhance teaching effectiveness: A 10-year update: BEME Guide No. 40.
(Taylor & Francis, 2016-07-15)BACKGROUND: This review, which focused on faculty development initiatives designed to improve teaching effectiveness, synthesized findings related to intervention types, study characteristics, individual and organizational ... -
The Effects of Fat Harvesting and Preparation, Air Exposure, Obesity, and Stem Cell Enrichment on Adipocyte Viability Prior to Graft Transplantation
(Oxford University Press, 2016-07-29)Background: Adipocyte viability is affected by fat preparation and processing methods, but rigorous and objective studies of these relationships are lacking. Objectives: The authors conducted a comprehensive evaluation ... -
Treatment of Fabry's Disease with the Pharmacologic Chaperone Migalastat.
(Massachusetts Medical Society, 2016-08-11)BACKGROUND: Fabry's disease, an X-linked disorder of lysosomal α-galactosidase deficiency, leads to substrate accumulation in multiple organs. Migalastat, an oral pharmacologic chaperone, stabilizes specific mutant forms ... -
Hepatotoxicity Induced by Coxibs: How Concerned Should We Be?
(Taylor & Francis, 2016-08-26)Introduction: The selective inhibitors of COX-2, coxibs, are nonsteroidal anti-inflammatory drugs (NSAIDs) that have much better gastrointestinal safety profile as compared with non-selective NSAIDs. In this review, we ... -
Hodgkin lymphoma burden in Central and South America.
(Elsevier, 2016-09)RATIONALE AND OBJECTIVE: Hodgkin lymphoma (HL) is largely curable owing to improvements in treatment since the 1960s; nevertheless, high mortality rates have been reported in Central and South America. We describe the ... -
Los trastornos obsesivo-compulsivos y sus manifestaciones cutáneas
(Educación médica continua, 2016-09-03)Self-inflicted dermatoses can cause severe tissue damage and distress in social life, school or work. Largely classified as an impulse control disorder, they are now considered as part of the obsessive-compulsive spectrum ... -
Hyponatremia and bone disease
(Springer Verlag, 2016-09-24)Hip fractures represent a serious health risk in the elderly, causing substantial morbidity and mortality. There is now a considerable volume of literature suggesting that chronic hyponatremia increases the adjusted odds ... -
International variations in application of the best-interest standard across the age spectrum.
(Springer Nature [academic journals on nature.com, 2016-10-13)OBJECTIVE: Ethically and legally, assertions that resuscitation is in a patient's best interest should be inversely correlated with willingness to forego intensive care (and accept comfort care) at the surrogate's request. ... -
South American investigation on professionalism: a theoretical framework.
(John Wiley & Sons Ltd and The Association for the Study of Medical Education, 2016-10-18) -
Cell Death Mechanisms in Human Chronic Liver Diseases: A Far Cry From Clinical Applicability
(Portland Press, 2016-10-20)The liver is constantly exposed to a host of injurious stimuli. This results in hepatocellular death mainly by apoptosis and necrosis, but also due to autophagy, necroptosis, pyroptosis and in some cases by an intricately ... -
Association Between Cigarette Smoking Prevalence and Income Level: A Systematic Review and Meta-Analysis
(Oxford University Press, 2016-10-26)Introduction Previous evidence linked low socioeconomic status with higher smoking prevalence. Our objective was to assess the strength of this association in the world population, updating a previous work. Methods Systematic ... -
Liver transplantation for hepatocellular carcinoma: evaluation of the alpha-fetoprotein model in a multicenter cohort from Latin America.
(Wiley, 2016-11-01)BACKGROUND & AIMS: The French alpha-fetoprotein (AFP) model has recently shown superior results compared to Milan criteria (MC) for prediction of hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) ... -
Chronic hyperprolactinemia evoked by disruption of lactotrope dopamine D2 receptors impacts on liver and adipocyte genes related to glucose and insulin balance.
(American Physiological Society, 2016-11-01)We studied the impact of high prolactin titers on liver and adipocyte gene expression related to glucose and insulin homeostasis in correlation with obesity onset. To that end we used mutant female mice that selectively ... -
The damping effect of cement as a potential mitigation factor of squeaking in ceramic-on-ceramic total hip arthroplasty
(British Editorial Society of Bone and Joint Surgery, 2016-11-03)Objectives Studies reporting specifically on squeaking in total hip arthroplasty have focused on cementless, and not on hybrid, fixation. We hypothesised that the cement mantle of the femur might have a damping effect on ... -
Involvement of hepatic macrophages in the antifibrotic effect of IGF-I_overexpressing mesenchymal stromal cells.
(BMC (part of Springer Nature), 2016-11-22)BACKGROUND: Cirrhosis is a major health problem worldwide and new therapies are needed. Hepatic macrophages (hMø) have a pivotal role in liver fibrosis, being able to act in both its promotion and its resolution. It is ... -
The Process of Lipid Storage in Insect Oocytes: The Involvement of β-Chain of ATP Synthase in Lipophorin-Mediated Lipid Transfer in the Chagas' Disease Vector Panstrongylus Megistus (Hemiptera: Reduviidae)
(Elsevier B.V. ScienceDirect, 2017-01-01)Lipophorin is the main lipoprotein in the hemolymph of insects. During vitellogenesis, lipophorin delivers its hydrophobic cargo to developing oocytes by its binding to non-endocytic receptors at the plasma membrane of the ...