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A familiar study on self-limited childhood epilepsy patients using hIPSC-derived neurons shows a bias towards immaturity at the morphological, electrophysiological and gene expression levels
(BMC, 2021-11-01)
Background: Self-limited Childhood Epilepsies are the most prevalent epileptic syndrome in children. Its pathogenesis is unknown. In this disease, symptoms resolve spontaneously in approximately 50% of patients when maturity ...
[A functional platform to monitor SARS-CoV-2-specific T cell responses in vaccinated individuals and COVID-19 recovered patients]
(Medicina Buenos Aires, 2021-07-01)
Abstract in English, Spanish
The rapid spread of the SARS-CoV-2, the causative agent of the emergent pandemic disease COVID-19, requires the urgent commitment of the immunology community to understand the adaptive immune ...
A few challenges in mucopolysaccharidosis type I
(2021-06-01)
RESUMEN
Se describen como desafíos actuales en
mucopolisacaridosis I la necesidad de una
clasificación adecuada, vinculándola a las
indicaciones terapéuticas; el diagnóstico
temprano desde la pesquisa neonatal, ...
Acute peritoneal dialysis, complications and outcomes in 389 children with STEC-HUS: a multicenter experience
(Springer [Commercial Publisher], 2021-06-01)
Abstract
Background: Management of acute kidney injury (AKI) in children with hemolytic uremic syndrome induced by a Shiga toxin-producing Escherichia coli infection (STEC-HUS) is supportive; however, 40 to 60% of cases ...
A Year of Living Dangerously: Challenges and Recommendations for Safely Performing Ophthalmic Surgery During the COVID-19 Pandemic, from Start to Finish
(Taylor and Francis Group [Commercial Publisher] Dove Press [Imprint], 2021-01-15)
Abstract
The COVID-19 pandemic has forced all nations to take an active role in infection control incorporating recommendations and measures to control viral dissemination. The epidemiological impact is very diverse and ...
Nicotine Neurotoxicity Involves Low Wnt1 Signaling in Spinal Locomotor Networks of the Postnatal Rodent Spinal Cord
(MDPI, 2021-09)
Abstract
The postnatal rodent spinal cord in-vitro is a useful model to investigate early pathophysiological changes after injury. While low dose nicotine (1 µM) induces neuroprotection, how higher doses affect spinal ...
Optical clearing reveals TNBS-induced morphological changes of VGLUT2-positive nerve fibers in mouse colorectum
(American Physiological Society, 2021-04)
Abstract
Colorectal hypersensitivity and sensitization of both mechanosensitive and mechanically insensitive afferents develop after intracolonic instillation of 2,4,6-trinitrobenzenesulfonic acid (TNBS) in the mouse, a ...
Multiprong control of glioblastoma multiforme invasiveness: blockade of pro-inflammatory signaling, anti-angiogenesis, and homeostasis restoration
(Springer, 2021-09)
Abstract
Glioblastoma multiforme (GBM) is the most invasive type of glial tumor with poor overall survival, despite advances in surgical resection, chemotherapy, and radiation. One of the main challenges in treating GBM ...
New insights into oxidative stress and immune mechanisms involved in age-related macular degeneration tackled by novel therapies
(Elsevier, 2021-05)
Abstract
The prevalence of age-related macular degeneration (AMD) has increased in the last years. Although anti-VEGF agents have improved the prognosis of exudative AMD, dry AMD has still devastating effects on elderly ...
dockECR: Open consensus docking and ranking protocol for virtual screening of small molecules
(Elsevier, 2021-12)
Abstract
The development of open computational pipelines to accelerate the discovery of treatments for emerging diseases allows finding novel solutions in shorter periods of time. Consensus molecular docking is one of ...