Browsing Investigación básica. by Author "Brumovsky, Pablo."
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IMT504 Provides Analgesia by Modulating Cell Infiltrate and Inflammatory Milieu in a Chronic Pain Model
Brumovsky, Pablo.; Villar, Marcelo.; Tate, Pablo.; Et al. (Springer [Commercial Publisher], 2021-09)Abstract IMT504 is a non-CPG, non-coding synthetic oligodeoxinucleotide (ODN) with immunomodulatory properties and a novel inhibitory role in pain transmission, exerting long-lasting analgesic effects upon multiple systemic ... -
Intrathecal Administration of an Anti-nociceptive Non-CpG Oligodeoxynucleotide Reduces Glial Activation and Central Sensitization
Leiguarda, C.; Villar, Marcelo.; Brumovsky, Pablo.; Et al. (Springer, 2021-12)Abstract Inflammatory pain associates with spinal glial activation and central sensitization. Systemic administration of IMT504, a non-CpG oligodeoxynucleotide originally designed as an immunomodulator, exerts remarkable ... -
Optical clearing reveals TNBS-induced morphological changes of VGLUT2-positive nerve fibers in mouse colorectum
Brumovsky, Pablo.; Guo, Tiantian.; Patel, Shivam.; Et al. (American Physiological Society, 2021-04)Abstract Colorectal hypersensitivity and sensitization of both mechanosensitive and mechanically insensitive afferents develop after intracolonic instillation of 2,4,6-trinitrobenzenesulfonic acid (TNBS) in the mouse, a ...