Browsing Investigación básica. by Author "Atorrasagasti, Catalina."
Now showing items 1-3 of 3
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4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice
Rodriguez, Marcelo.; Onorato, Agostina.; Cantero, María.; Domínguez, Luciana.; Bayo, Juan.; Fiore, Esteban.; García, Mariana.; Atorrasagasti, Catalina.; Cambay, Ali.; Malvicini, Mariana.; Mazzolini, Guillermo. (Nature Research, 2021-03-01)Hepatocellular carcinoma (HCC) arises in the setting of advanced liver fibrosis, a dynamic and complex inflammatory disease. The tumor microenvironment (TME) is a mixture of cellular components including cancer cells, ... -
Acceleration of TAA-Induced Liver Fibrosis by Stress Exposure Is Associated with Upregulation of Nerve Growth Factor and Glycopattern Deviations
Atorrasagasti, Catalina.; Cantero, María.; Mazzolini, Guillermo.; García, Mariana.; Et al. (MDPI [Commercial Publisher], 2021-05-01)Abstract Liver fibrosis results from many chronic injuries and may often progress to cirrhosis and hepatocellular carcinoma (HCC). In fact, up to 90% of HCC arise in a cirrhotic liver. Conversely, stress is implicated in ... -
Significance of Simple Steatosis: An Update on the Clinical and Molecular Evidence
Mazzolini, Guillermo.; Sowa, Jan-Peter.; Atorrasagasti, Catalina.; Et al. (MDPI [Commercial Publisher], 2020-11)Abstract Non-alcoholic fatty liver disease (NAFLD) is defined clinicopathologically by the accumulation of lipids in >5% of hepatocytes and the exclusion of secondary causes of fat accumulation. NAFLD encompasses a wide ...