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Loss of dystrophin is associated with increased myocardial stiffness in a model of left ventricular hypertrophy.
(Springer, 2017-03-18)
Transition from compensated to decompensated left ventricular hypertrophy (LVH) is accompanied by functional and structural changes. Here, the aim was to evaluate dystrophin expression in murine models and human subjects ...
Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease.
(Massachusetts Medical Society, 2017-11-16)
BACKGROUND:
In a previous trial involving patients with early autosomal dominant polycystic kidney disease (ADPKD; estimated creatinine clearance, ≥60 ml per minute), the vasopressin V2-receptor antagonist tolvaptan slowed ...
The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants
(Springer Nature [academic journals on nature.com], 2017-01-01)
We studied 298 patients with severe aplastic anaemia (SAA) allografted in four Latin American countries. The source of cells was bone marrow (BM) in 94 patients and PBSCs in 204 patients. Engraftment failed in 8.1% of ...
Transforming growth factor-β1 functional polymorphisms in myeloablative sibling hematopoietic stem cell transplantation
(Springer Nature [academic journals on nature.com], 2017-05-01)
Hematopoietic stem cell transplantation (HSCT) with sibling donors (s.d.) is a life-saving intervention for patients with hematological malignancies. Numerous genetic factors have a role in transplant outcome. Several ...
Association Between Cigarette Smoking Prevalence and Income Level: A Systematic Review and Meta-Analysis.
(Oxford University Press, 2017-09)
INTRODUCTION:
Previous evidence linked low socioeconomic status with higher smoking prevalence. Our objective was to assess the strength of this association in the world population, updating a previous work.
METHODS: ...