Definition, aims, and implementation of GA2 LEN/HAEi Angioedema Centers of Reference and Excellence

Abstract

Definition, aims, and implementation of GA2 LEN/HAEi Angioedema Centers of Reference and Excellence To the Editor, GA2 LEN, the Global Allergy and Asthma European Network, and HAE international (HAEi), the global umbrella organization for the world's hereditary angioedema (HAE) patient groups, have launched their joint ACARE (Angioedema Center of Reference and Excellence) program, within GA2 LEN’s center of reference and excellence (CORE) initiative. Angioedema is a common, heterogeneous, often debilitating and chronic condition and is frequently a challenge for physicians and affected patients, especially patients suffering from recurrent attacks. Additionally, it can be a challenge for some patients to understand the underlying etiology of their angioedema (Table 1). GA2 LEN’s CORE networks, such as UCARE for urticaria and ADCARE for atopic dermatitis, help to improve the management of difficult-to-treat conditions. Here, we describe the aims, requirements, provisions, application process, audit, and accreditation protocol for GA2 LEN/HAEi ACAREs. ACAREs aim to provide excellence in angioedema management, increase the knowledge of angioedema through research and education, and promote advocacy activities that raise angioedema awareness. To become a certified ACARE, angioedema centers must fulfill 32 requirements, defined by specific provisions that will be assessed during an audit visit. The ACARE program will result in a strong network of angioedema specialists, promote angioedema research and awareness, and harmonize and improve angioedema management globally. ACAREs will expand access to modern angioedema medicines in countries where they are available and help to bring them to countries where they are not.1