Browsing by Author "Malvicini, Mariana."
Now showing items 1-6 of 6
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4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice
Rodriguez, Marcelo.; Onorato, Agostina.; Cantero, María.; Domínguez, Luciana.; Bayo, Juan.; Fiore, Esteban.; García, Mariana.; Atorrasagasti, Catalina.; Cambay, Ali.; Malvicini, Mariana.; Mazzolini, Guillermo. (Nature Research, 2021-03-01)Hepatocellular carcinoma (HCC) arises in the setting of advanced liver fibrosis, a dynamic and complex inflammatory disease. The tumor microenvironment (TME) is a mixture of cellular components including cancer cells, ... -
EXPRESIÓN DEL FACTOR ESTIMULANTE DE COLONIAS DE MACRÓFAGOS Y GRANULOCITOS EN CÉLULAS MESENQUIMALES ESTROMALES MEDIANTE ARNm TRANSCRIPTO IN VITRO. UNA ESTRATEGIA TERAPÉUTICA PARA EL HEPATOCARCINOMA CELULAR
Cantero, María José (2024-12)Resumen Las células estromales mesenquimales (MSC) se han utilizado como transportadoras de agentes antitumorales debido a su capacidad de migrar y anclarse a tumores. El ARNm transcripto in vitro (ARNm IVT) es una ... -
Immunotherapy for Hepatocellular Carcinoma: Is Latin America Ready for Primetime?
Mazzolini, Guillermo.; Malvicini, Mariana.; Bayo, Juan.; Et al. (AASLD, 2020-09)Potential conflict of interest: Nothing to report. Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer‐related death worldwide, and its mortality is increasing steadily.1 HCC incidence has grown in the ... -
Involvement of hepatic macrophages in the antifibrotic effect of IGF-I_overexpressing mesenchymal stromal cells.
Fiore, Esteban.; Malvicini, Mariana.; Bayo, Juan.; Peixoto, Estanislao.; Atorrasagasti, Catalina.; Sierra, Romina.; Rodriguez, Marcelo. (BMC (part of Springer Nature), 2016-11-22)BACKGROUND: Cirrhosis is a major health problem worldwide and new therapies are needed. Hepatic macrophages (hMø) have a pivotal role in liver fibrosis, being able to act in both its promotion and its resolution. It is ... -
Remodelación del microambiente tumoral por 4-Metilumbelliferona e inmunoterapia génica en el hepatocarcinoma asociado a cirrosis: implicancias sobre las Cancer Stem Cells.
Rodríguez, Marcelo. (2020-12)RESUMEN El hepatocarcinoma (HCC) es el tumor hepático primario más frecuente, y su incidencia y mortalidad se encuentran en aumento. El HCC se desarrolla en hígados con fibrosis avanzada o cirrosis subyacente, en donde ... -
SPARC gene deletion protects against toxic liver injury and is associated to an enhanced proliferative capacity and reduced oxidative stress response.
Peixoto, Estanislao; Atorrasagasti, Catalina.; Malvicini, Mariana.; Fiore, Esteban.; Rodriguez, Marcelo.; Garcia, Mariana.; Finocchieto, Paola.; Poderoso, Fernando.; et al. (Oncotarget, 2016-06-25)SPARC, also known as osteonectin and BM-40, is a matricellular protein with a number of biological functions. Hepatic SPARC expression is induced in response to thioacetamide, bile-duct ligation, and acute injuries such ...