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SPARC gene deletion protects against toxic liver injury and is associated to an enhanced proliferative capacity and reduced oxidative stress response.
(Oncotarget, 2016-06-25)
SPARC, also known as osteonectin and BM-40, is a matricellular protein with a number of biological functions. Hepatic SPARC expression is induced in response to thioacetamide, bile-duct ligation, and acute injuries such ...
Impacto de una intervención educativa para mejorar la adherencia a las recomendaciones sobre sueño seguro del lactante.
(Sociedad Argentina de Pediatria, 2016-04-25)
Introducción. Las campañas públicas en países
desarrollados con recomendaciones para el
sueño seguro del lactante lograron aumentar la
adherencia a la posición supina para dormir a
más del 70% y generaron, simultáneamente, ...
Loss of dystrophin is associated with increased myocardial stiffness in a model of left ventricular hypertrophy.
(Springer, 2017-03-18)
Transition from compensated to decompensated left ventricular hypertrophy (LVH) is accompanied by functional and structural changes. Here, the aim was to evaluate dystrophin expression in murine models and human subjects ...
Biomarker-driven phenotyping in Parkinson's disease: A translational missing link in disease-modifying clinical trials.
(Wiley, 2017-02-24)
Past clinical trials of putative neuroprotective therapies have targeted PD as a single pathogenic disease entity. From an Oslerian clinicopathological perspective, the wide complexity of PD converges into Lewy bodies and ...
The early onset of type 1 autoimmune hepatitis has a strong genetic influence: role of HLA and KIR genes.
(Springer Nature Switzerland AG. Springer is part of Springer Nature, 2016-02-18)
We have previously reported a strong association between HLA-DRB1*1301 and type 1 pediatric autoimmune hepatitis (PAH) and between HLA-DR*0405 and adult autoimmune hepatitis (AAH). Because human killer cell immunoglobulin-like ...
Treatment of Fabry's Disease with the Pharmacologic Chaperone Migalastat.
(Massachusetts Medical Society, 2016-08-11)
BACKGROUND:
Fabry's disease, an X-linked disorder of lysosomal α-galactosidase deficiency, leads to substrate accumulation in multiple organs. Migalastat, an oral pharmacologic chaperone, stabilizes specific mutant forms ...
Liver transplantation for hepatocellular carcinoma: evaluation of the alpha-fetoprotein model in a multicenter cohort from Latin America.
(John Wiley & Sons A/S, 2016-05-05)
BACKGROUND & AIMS:
The French alpha-fetoprotein (AFP) model has recently shown superior results compared to Milan criteria (MC) for prediction of hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) ...
Association Between Cigarette Smoking Prevalence and Income Level: A Systematic Review and Meta-Analysis.
(Oxford University Press, 2017-09)
INTRODUCTION:
Previous evidence linked low socioeconomic status with higher smoking prevalence. Our objective was to assess the strength of this association in the world population, updating a previous work.
METHODS: ...
Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1: phenotype and genotype correlations in 71 patients.
(John Wiley & Sons, Inc. All rights reserved, 2016-03-01)
BACKGROUND:
The encephalomyopathic mtDNA depletion syndrome with methylmalonic aciduria is associated with deficiency of succinate-CoA ligase, caused by mutations in SUCLA2 or SUCLG1. We report here 25 new patients with ...
International variations in application of the best-interest standard across the age spectrum.
(Springer Nature [academic journals on nature.com], 2017-02-01)
OBJECTIVE:
Ethically and legally, assertions that resuscitation is in a patient's best interest should be inversely correlated with willingness to forego intensive care (and accept comfort care) at the surrogate's request. ...