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Cell Death Mechanisms in Human Chronic Liver Diseases: A Far Cry From Clinical Applicability
(Portland Press, 2016-10-20)
The liver is constantly exposed to a host of injurious stimuli. This results in hepatocellular death mainly by apoptosis and necrosis, but also due to autophagy, necroptosis, pyroptosis and in some cases by an intricately ...
A Comprensive study of epigenetic alterations in hepatocellular carcicoma identifies potencial therapeutic targets.
(Elsevier B.V. All rights reserved, 2019-07-01)
Abstract
Background & aims: A causal link has recently been established between epigenetic alterations and hepatocarcinogenesis, indicating that epigenetic inhibition may have therapeutic potential. We aimed to identify ...
Development of an Improved Guanidine-Based Rac1 Inhibitor with in vivo Activity against Non-Small Cell Lung Cancer
(Wiley, 2021-03)
Abstract
The Rho GTPase Rac1 is involved in the control of cytoskeleton reorganization and other fundamental cellular functions. Aberrant activity of Rac1 and its regulators is common in human cancer. In particular, ...
Controlling cholesterol entry into mitochondria, a key step for hepatocarcinogenesis in non-alcoholic steatohepatitis-related hepatocellular carcinoma
(AME Publishing, 2021-12)
Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading cause of cancer-related death worldwide (1). Unfortunately, the incidence and mortality of HCC are increasing steadily in formerly ...
Alcohol consumption leads to loss of healthy life, but the ADH1B*2 allele may still protect from NASH
(AME Publishing [Commercial Publisher], 2021-06-01)
La enfermedad del hígado graso no alcohólico (NAFLD, por sus siglas en inglés) es ahora la causa más común de enfermedad hepática crónica en todo el mundo, afecta a casi una cuarta parte de la población mundial ( 1 , 2 ) ...
Chronic hyperprolactinemia evoked by disruption of lactotrope dopamine D2 receptors impacts on liver and adipocyte genes related to glucose and insulin balance.
(American Physiological Society, 2016-11-01)
We studied the impact of high prolactin titers on liver and adipocyte gene expression related to glucose and insulin homeostasis in correlation with obesity onset. To that end we used mutant female mice that selectively ...
Hepatokines and adipokines in NASH-related hepatocellular carcinoma
(Elsevier, 2021-02)
Abstract
The incidence of hepatocellular carcinoma (HCC) is increasing in industrialised societies; this is likely secondary to the increasing burden of non-alcoholic fatty liver disease (NAFLD), its progressive form ...
Acceleration of TAA-Induced Liver Fibrosis by Stress Exposure Is Associated with Upregulation of Nerve Growth Factor and Glycopattern Deviations
(MDPI [Commercial Publisher], 2021-05-01)
Abstract
Liver fibrosis results from many chronic injuries and may often progress to cirrhosis and hepatocellular carcinoma (HCC). In fact, up to 90% of HCC arise in a cirrhotic liver. Conversely, stress is implicated in ...
4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice
(Nature Research, 2021-03-01)
Hepatocellular carcinoma (HCC) arises in the setting of advanced liver fibrosis, a dynamic and complex inflammatory disease. The tumor microenvironment (TME) is a mixture of cellular components including cancer cells, ...
Significance of Simple Steatosis: An Update on the Clinical and Molecular Evidence
(MDPI [Commercial Publisher], 2020-11)
Abstract
Non-alcoholic fatty liver disease (NAFLD) is defined clinicopathologically by the accumulation of lipids in >5% of hepatocytes and the exclusion of secondary causes of fat accumulation. NAFLD encompasses a wide ...