Browsing by Author "Rodriguez, Marcelo."
Now showing items 1-4 of 4
-
4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice
Rodriguez, Marcelo.; Onorato, Agostina.; Cantero, María.; Domínguez, Luciana.; Bayo, Juan.; Fiore, Esteban.; García, Mariana.; Atorrasagasti, Catalina.; Cambay, Ali.; Malvicini, Mariana.; Mazzolini, Guillermo. (Nature Research, 2021-03-01)Hepatocellular carcinoma (HCC) arises in the setting of advanced liver fibrosis, a dynamic and complex inflammatory disease. The tumor microenvironment (TME) is a mixture of cellular components including cancer cells, ... -
Involvement of hepatic macrophages in the antifibrotic effect of IGF-I_overexpressing mesenchymal stromal cells.
Fiore, Esteban.; Malvicini, Mariana.; Bayo, Juan.; Peixoto, Estanislao.; Atorrasagasti, Catalina.; Sierra, Romina.; Rodriguez, Marcelo. (BMC (part of Springer Nature), 2016-11-22)BACKGROUND: Cirrhosis is a major health problem worldwide and new therapies are needed. Hepatic macrophages (hMø) have a pivotal role in liver fibrosis, being able to act in both its promotion and its resolution. It is ... -
SPARC gene deletion protects against toxic liver injury and is associated to an enhanced proliferative capacity and reduced oxidative stress response.
Peixoto, Estanislao; Atorrasagasti, Catalina.; Malvicini, Mariana.; Fiore, Esteban.; Rodriguez, Marcelo.; Garcia, Mariana.; Finocchieto, Paola.; Poderoso, Fernando.; et al. (Oncotarget, 2016-06-25)SPARC, also known as osteonectin and BM-40, is a matricellular protein with a number of biological functions. Hepatic SPARC expression is induced in response to thioacetamide, bile-duct ligation, and acute injuries such ... -
Two Synchronous Neonatal Tumors: An Extremely Rare Case
Rodriguez, Marcelo.; Albarenque, K.; Lagues, C.; et al. (Hindawi, 2021-04)Abstract We report a case of a newborn with two synchronous tumors-sialoblastoma and hepatoblastoma-diagnosed at 20 weeks of gestation by magnetic resonance imaging (MRI) and ultrasonography (US). The aim of this study ...