Browsing by Author "Mazzone, Graciela."
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Circular RNAs: The Novel Actors in Pathophysiology of Spinal Cord Injury
Mazzone, Graciela.; Sámano, Cynthia.; Mladinic, Miranda. (Frontiers Media, 2021-10)Abstract Spinal Cord Injury (SCI) can elicit a progressive loss of nerve cells promoting disability, morbidity, and even mortality. Despite different triggering mechanisms, a cascade of molecular events involving complex ... -
GABAergic Mechanisms Can Redress the Tilted Balance between Excitation and Inhibition in Damaged Spinal Networks
Mazzone, Graciela.; Aquino, Jorge.; Nistri, Andrea.; Et al. (Springer, 2021-08)Abstract Correct operation of neuronal networks depends on the interplay between synaptic excitation and inhibition processes leading to a dynamic state termed balanced network. In the spinal cord, balanced network activity ... -
Nicotine Neurotoxicity Involves Low Wnt1 Signaling in Spinal Locomotor Networks of the Postnatal Rodent Spinal Cord
Mazzone, Graciela.; Kaur, Jaspreet.; Aquino, Jorge.; Et al. (MDPI, 2021-09)Abstract The postnatal rodent spinal cord in-vitro is a useful model to investigate early pathophysiological changes after injury. While low dose nicotine (1 µM) induces neuroprotection, how higher doses affect spinal ...