Browsing by Author "Brumovsky, Pablo."
Now showing items 1-6 of 6
-
Dorsal root ganglion neurons and tyrosine hydroxylase--an intriguing association with implications for sensation and pain.
Brumovsky, Pablo. (International Association for the Study of Pain, 2016-02-01)Tyrosine hydroxylase (TH) is a rate-limiting enzyme broadly expressed in noradrenergic and dopaminergic neurons in the central nervous system [57,70]. TH is also expressed by peripheral sympathetic neurons [98] as well ... -
IMT504 Provides Analgesia by Modulating Cell Infiltrate and Inflammatory Milieu in a Chronic Pain Model
Brumovsky, Pablo.; Villar, Marcelo.; Tate, Pablo.; Et al. (Springer [Commercial Publisher], 2021-09)Abstract IMT504 is a non-CPG, non-coding synthetic oligodeoxinucleotide (ODN) with immunomodulatory properties and a novel inhibitory role in pain transmission, exerting long-lasting analgesic effects upon multiple systemic ... -
Intrathecal Administration of an Anti-nociceptive Non-CpG Oligodeoxynucleotide Reduces Glial Activation and Central Sensitization
Leiguarda, C.; Villar, Marcelo.; Brumovsky, Pablo.; Et al. (Springer, 2021-12)Abstract Inflammatory pain associates with spinal glial activation and central sensitization. Systemic administration of IMT504, a non-CpG oligodeoxynucleotide originally designed as an immunomodulator, exerts remarkable ... -
Optical clearing reveals TNBS-induced morphological changes of VGLUT2-positive nerve fibers in mouse colorectum
Brumovsky, Pablo.; Guo, Tiantian.; Patel, Shivam.; Et al. (American Physiological Society, 2021-04)Abstract Colorectal hypersensitivity and sensitization of both mechanosensitive and mechanically insensitive afferents develop after intracolonic instillation of 2,4,6-trinitrobenzenesulfonic acid (TNBS) in the mouse, a ... -
Spinal neuropeptide expression and neuropathic behavior in the acute and chronic phases after spinal cord injury: Effects of progesterone administration.
Coronel, Maria F.; Villar, Marcelo.; Brumovsky, Pablo.; Gonzalez, Susana. (Elsevier Inc. All rights reserved., 2017-02)Patients with spinal cord injury (SCI) develop chronic pain that severely compromises their quality of life. We have previously reported that progesterone (PG), a neuroprotective steroid, could offer a promising therapeutic ... -
Systemic Transplantation of Bone Marrow Mononuclear Cells Promotes Axonal Regeneration and Analgesia in a Model of Wallerian Degeneration
Usach, Vanina.; Malet, Mariana.; López, Margarita.; Lavalle, Lucia.; Piñero, Gonzalo.; Saccoliti, María.; Brumovsky, Pablo. (Lippincott, Williams & Wilkins, 2017-07)Background Reinnervation timing after nerve injury is critical for favorable axonal regeneration, remyelination, and clinical improvement. Considering bone marrow mononuclear cells (BMMC) are easily obtained and readily ...